PMID- 23084641
OWN - NLM
STAT- MEDLINE
DCOM- 20130326
LR  - 20220409
IS  - 1879-0739 (Electronic)
IS  - 0271-5317 (Linking)
VI  - 32
IP  - 9
DP  - 2012 Sep
TI  - Green tea extract reverses endothelial dysfunction and reduces atherosclerosis 
      progression in homozygous knockout low-density lipoprotein receptor mice.
PG  - 684-93
LID - S0271-5317(12)00164-9 [pii]
LID - 10.1016/j.nutres.2012.08.003 [doi]
AB  - The aim of this study was to evaluate the effects of green tea extract (GTE) 
      administration on vascular reactivity and atherosclerosis progression in 
      low-density lipoprotein receptor knockout mice. We hypothesized that GTE intake 
      may ameliorate atherosclerosis by improving endothelial dysfunction. Animals (n = 
      12 per group) were fed a hypercholesterolemic diet and received either water or 
      GTE at a dose of 50, 100, or 300 mg/kg once a day by gavage (100 muL/10 g weight). 
      After 4 weeks, atherosclerosis extension and vascular reactivity were evaluated 
      in the aorta, and the levels of lipids, monocyte chemotactic protein-1 (MCP-1), 
      and tumor necrosis factor alpha were measured in the plasma. Administration of GTE at 
      a dose of 50 mg/kg significantly decreased the area of atherosclerotic lesions by 
      35%, improved the vascular reactivity in the isolated thoracic aorta, and lowered 
      the plasma levels of both MCP-1 and triglycerides. Delivery of 100 mg/kg of GTE 
      only promoted vasocontraction and vasorelaxation (P < .05), whereas a dose of 300 
      mg/kg was ineffective. Maximum contraction and relaxation negatively correlated 
      with the lesion area (r = -0.755 and -0.767, respectively), whereas the plasma 
      levels of MCP-1 and triglycerides positively correlated with plaque size (r = 
      0.549 and 0.421, respectively). In summary, our results supported the hypothesis 
      that administration of GTE at low doses may contribute to a decrease in 
      atherosclerosis progression by reversing endothelial dysfunction.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Minatti, Jaqueline
AU  - Minatti J
AD  - Department of Nutrition, Health Sciences Center, Federal University of Santa 
      Catarina, Florianopolis, SC, Brazil.
FAU - Wazlawik, Elisabeth
AU  - Wazlawik E
FAU - Hort, Mariana A
AU  - Hort MA
FAU - Zaleski, Fernanda L
AU  - Zaleski FL
FAU - Ribeiro-do-Valle, Rosa M
AU  - Ribeiro-do-Valle RM
FAU - Maraschin, Marcelo
AU  - Maraschin M
FAU - da Silva, Edson L
AU  - da Silva EL
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120903
PL  - United States
TA  - Nutr Res
JT  - Nutrition research (New York, N.Y.)
JID - 8303331
RN  - 0 (Antioxidants)
RN  - 0 (Biomarkers)
RN  - 0 (Ccl2 protein, mouse)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Lipoproteins, LDL)
RN  - 0 (Plant Extracts)
RN  - 0 (Receptors, LDL)
RN  - 0 (Tea)
RN  - 0 (Triglycerides)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 8R1V1STN48 (Catechin)
RN  - BQM438CTEL (epigallocatechin gallate)
RN  - EC 2.6.1.2 (Alanine Transaminase)
SB  - IM
MH  - Alanine Transaminase/metabolism
MH  - Animals
MH  - Antioxidants/*pharmacology
MH  - Aorta/drug effects/metabolism
MH  - Atherosclerosis/*drug therapy/pathology
MH  - Biomarkers/blood
MH  - Catechin/*analogs & derivatives/pharmacology
MH  - Chemokine CCL2/blood
MH  - Disease Models, Animal
MH  - Endothelium, Vascular/*drug effects/physiopathology
MH  - Female
MH  - Inflammation/drug therapy/pathology
MH  - Lipoproteins, LDL/blood
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Knockout
MH  - Plant Extracts/*pharmacology
MH  - Receptors, LDL/genetics
MH  - Tea/*chemistry
MH  - Triglycerides/blood
MH  - Tumor Necrosis Factor-alpha/blood
EDAT- 2012/10/23 06:00
MHDA- 2013/03/27 06:00
CRDT- 2012/10/23 06:00
PHST- 2011/12/11 00:00 [received]
PHST- 2012/07/31 00:00 [revised]
PHST- 2012/08/03 00:00 [accepted]
PHST- 2012/10/23 06:00 [entrez]
PHST- 2012/10/23 06:00 [pubmed]
PHST- 2013/03/27 06:00 [medline]
AID - S0271-5317(12)00164-9 [pii]
AID - 10.1016/j.nutres.2012.08.003 [doi]
PST - ppublish
SO  - Nutr Res. 2012 Sep;32(9):684-93. doi: 10.1016/j.nutres.2012.08.003. Epub 2012 Sep 
      3.