PMID- 23084982
OWN - NLM
STAT- MEDLINE
DCOM- 20130809
LR  - 20130115
IS  - 1873-3514 (Electronic)
IS  - 0028-3932 (Linking)
VI  - 51
IP  - 2
DP  - 2013 Jan
TI  - Deciphering the impact of cerebellar and basal ganglia dysfunction in accuracy 
      and variability of motor timing.
PG  - 267-74
LID - S0028-3932(12)00390-9 [pii]
LID - 10.1016/j.neuropsychologia.2012.09.018 [doi]
AB  - Studies in motor timing have shown that the basal ganglia and cerebellum play an 
      important role in temporal processing. Timing studies in Cerebellar/ataxic 
      Disorders (CD) and Parkinson's disease (PD) patients contrast the roles of the 
      cerebellum and basal ganglia in motor timing. Here, we used a 
      synchronization-continuation task to compare accuracy and variability of motor 
      timing during repetitive tapping. We compared data collected for the present 
      study - from patients with CD and healthy controls - to data from a previous 
      study with patients with PD. We asked participants to tap at Inter-stimulus 
      Intervals (ISIs) of 250, 500, 1000, and 2000 ms. Using Linear Mixed Models 
      (LMMs), we explored how ISI, Task Phase, and Diagnosis interacted to determine 
      the (i) the accuracy and (ii) the variability of tapping. In our analysis of 
      accuracy, we found evidence that during the synchronization phase, at ISI=250 ms, 
      CD patients lagged 'behind the beat'; whereas our previous work has suggested 
      that medicated PD patients hasten 'ahead of the beat'. In our analysis of 
      variability, we observed that at ISIs below 1000 ms, CD patients showed greater 
      variability in motor timing than the healthy controls, while PD patients showed 
      less variability than CD patients and healthy controls during the synchronization 
      phase at the 1000 ms ISI. These results highlight the differential performance on 
      explicit motor timing between patients with disorders of the cerebellum and basal 
      ganglia. Our results illustrate a novel approach to discerning cognitive control 
      of motor timing.
CI  - Copyright (c) 2012 Elsevier Ltd. All rights reserved.
FAU - Claassen, Daniel O
AU  - Claassen DO
AD  - Department of Neurology, Vanderbilt University, Nashville TN, USA. 
      daniel.claassen@vanderbilt.edu
FAU - Jones, Catherine R G
AU  - Jones CR
FAU - Yu, Minhong
AU  - Yu M
FAU - Dirnberger, Georg
AU  - Dirnberger G
FAU - Malone, Tim
AU  - Malone T
FAU - Parkinson, Michael
AU  - Parkinson M
FAU - Giunti, Paola
AU  - Giunti P
FAU - Kubovy, Michael
AU  - Kubovy M
FAU - Jahanshahi, Marjan
AU  - Jahanshahi M
LA  - eng
GR  - Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121016
PL  - England
TA  - Neuropsychologia
JT  - Neuropsychologia
JID - 0020713
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Basal Ganglia/pathology
MH  - Cerebellar Diseases/*complications
MH  - Cerebellum/*pathology
MH  - Female
MH  - Humans
MH  - Linear Models
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Parkinson Disease/*complications
MH  - Perceptual Disorders/*etiology
MH  - Time Perception/*physiology
EDAT- 2012/10/23 06:00
MHDA- 2013/08/10 06:00
CRDT- 2012/10/23 06:00
PHST- 2012/05/25 00:00 [received]
PHST- 2012/09/06 00:00 [revised]
PHST- 2012/09/12 00:00 [accepted]
PHST- 2012/10/23 06:00 [entrez]
PHST- 2012/10/23 06:00 [pubmed]
PHST- 2013/08/10 06:00 [medline]
AID - S0028-3932(12)00390-9 [pii]
AID - 10.1016/j.neuropsychologia.2012.09.018 [doi]
PST - ppublish
SO  - Neuropsychologia. 2013 Jan;51(2):267-74. doi: 
      10.1016/j.neuropsychologia.2012.09.018. Epub 2012 Oct 16.