PMID- 23085027
OWN - NLM
STAT- MEDLINE
DCOM- 20130502
LR  - 20240321
IS  - 1879-0712 (Electronic)
IS  - 0014-2999 (Linking)
VI  - 697
IP  - 1-3
DP  - 2012 Dec 15
TI  - Effects of salvianolic acid B on survival, self-renewal and neuronal 
      differentiation of bone marrow derived neural stem cells.
PG  - 32-9
LID - S0014-2999(12)00854-0 [pii]
LID - 10.1016/j.ejphar.2012.10.008 [doi]
AB  - Our previous study has demonstrated the therapeutic potential of bone marrow 
      derived-neural stem cells (BM-NSCs) in CNS disorders; however, the beneficial 
      effects are modest due to the poor survival and low neural differentiation 
      frequency. Here, we demonstrate that salvianolic acid B (Sal B), a potent aqueous 
      of a well known Chinese medicine herb, Salvia miltiorrhiza, possesses the ability 
      to promote BM-NSCs proliferation in a dose dependent manner as verified by growth 
      curve and Bromodeoxyuridine (BrdU) incorporation assays; While in differentiation 
      medium, Sal B promoted nestin(+) BM-NSCs differentiated into greater numbers of 
      NF-M(+) neurons and NG2(+) oligodendrocyte precursors, but fewer GFAP(+) 
      astrocytes as verified by triple immunostaining and quantitative analysis; upon 
      exposure to H(2)O(2), Sal B facilitated the cells survival, reduced LDH leakage, 
      and inhibited apoptosis, displaying a dose-dependent neuroprotective effect on 
      BM-NSCs. Sal B induced brain-derived neurotrophic factor (BDNF) production by 
      BM-NSCs, which may be beneficial for the cells survival and differentiation in 
      unfavourable environment. The collective evidence indicates that Sal B may be a 
      potential drug to upgrade the therapeutic efficiency of BM-NSCs in CNS diseases.
CI  - Copyright (c) 2012 Elsevier B.V. All rights reserved.
FAU - Zhang, Nan
AU  - Zhang N
AD  - School of Pharmacy, Liaoning University of Traditional Chinese Medicine, 77 Sheng 
      Ming Yi Lu, Dalian, Liaoning 116600, China.
FAU - Kang, Tingguo
AU  - Kang T
FAU - Xia, Yang
AU  - Xia Y
FAU - Wen, Qingping
AU  - Wen Q
FAU - Zhang, Xiaodan
AU  - Zhang X
FAU - Li, Hongyan
AU  - Li H
FAU - Hu, Yv
AU  - Hu Y
FAU - Hao, Haiguang
AU  - Hao H
FAU - Zhao, Dan
AU  - Zhao D
FAU - Sun, Dong
AU  - Sun D
FAU - Yan, Yaping
AU  - Yan Y
FAU - Zhang, Guang-Xian
AU  - Zhang GX
FAU - Yang, Jingxian
AU  - Yang J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Retracted Publication
DEP - 20121018
PL  - Netherlands
TA  - Eur J Pharmacol
JT  - European journal of pharmacology
JID - 1254354
RN  - 0 (Antigens)
RN  - 0 (Benzofurans)
RN  - 0 (Biomarkers)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Glial Fibrillary Acidic Protein)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Neurofilament Proteins)
RN  - 0 (Neuroprotective Agents)
RN  - 0 (Oxidants)
RN  - 0 (Proteoglycans)
RN  - 0 (chondroitin sulfate proteoglycan 4)
RN  - 0 (glial fibrillary astrocytic protein, mouse)
RN  - 111365-29-8 (neurofilament protein M)
RN  - BBX060AN9V (Hydrogen Peroxide)
RN  - C1GQ844199 (salvianolic acid B)
RN  - EC 1.1.1.27 (L-Lactate Dehydrogenase)
SB  - IM
RIN - Eur J Pharmacol. 2024 Apr 15;969:176347. PMID: 38458941
MH  - Animals
MH  - Antigens/metabolism
MH  - Apoptosis/drug effects
MH  - Benzofurans/*pharmacology
MH  - Biomarkers/metabolism
MH  - Bone Marrow Cells/*drug effects/metabolism/pathology
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Cell Proliferation/*drug effects
MH  - Cell Survival/drug effects
MH  - Cytoprotection
MH  - Dose-Response Relationship, Drug
MH  - Glial Fibrillary Acidic Protein
MH  - Hydrogen Peroxide/toxicity
MH  - Immunohistochemistry
MH  - L-Lactate Dehydrogenase/metabolism
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Nerve Tissue Proteins/metabolism
MH  - Neural Stem Cells/*drug effects/metabolism/pathology
MH  - Neurofilament Proteins/metabolism
MH  - Neurogenesis/*drug effects
MH  - Neuroprotective Agents/*pharmacology
MH  - Oxidants/toxicity
MH  - Phenotype
MH  - Proteoglycans/metabolism
MH  - Spheroids, Cellular
MH  - Time Factors
EDAT- 2012/10/23 06:00
MHDA- 2013/05/03 06:00
CRDT- 2012/10/23 06:00
PHST- 2012/05/08 00:00 [received]
PHST- 2012/09/28 00:00 [revised]
PHST- 2012/10/06 00:00 [accepted]
PHST- 2012/10/23 06:00 [entrez]
PHST- 2012/10/23 06:00 [pubmed]
PHST- 2013/05/03 06:00 [medline]
AID - S0014-2999(12)00854-0 [pii]
AID - 10.1016/j.ejphar.2012.10.008 [doi]
PST - ppublish
SO  - Eur J Pharmacol. 2012 Dec 15;697(1-3):32-9. doi: 10.1016/j.ejphar.2012.10.008. 
      Epub 2012 Oct 18.