PMID- 23085218
OWN - NLM
STAT- MEDLINE
DCOM- 20131017
LR  - 20130415
IS  - 1873-7544 (Electronic)
IS  - 0306-4522 (Linking)
VI  - 239
DP  - 2013 Jun 3
TI  - Sex differences and the role of estrogen in animal models of schizophrenia: 
      interaction with BDNF.
PG  - 67-83
LID - S0306-4522(12)01032-9 [pii]
LID - 10.1016/j.neuroscience.2012.10.024 [doi]
AB  - Schizophrenia is a severe psychiatric disorder with a complex and variable set of 
      symptoms. Both genetic and environmental mechanisms are involved in the 
      development of the illness and lead to structural and neurochemical abnormalities 
      in the brain. An intriguing facet of schizophrenia is sex differences, which have 
      been described for nearly all features of the illness, including the peak age of 
      onset, symptoms and treatment response. The ovarian hormone, estrogen, may be 
      protective against schizophrenia and evidence is accumulating that estrogen may 
      exert this effect via an interaction with brain-derived neurotrophic factor 
      (BDNF). Both estrogen and BDNF have trophic effects on the developing brain and 
      promote synaptic plasticity and maintain neurons well into adulthood. Major 
      neurotransmitter systems including dopaminergic, serotonergic and glutamatergic 
      pathways are modulated and supported by estrogen and BDNF. Despite their 
      commonalities, estrogen and BDNF have mostly been examined independently but 
      increasing evidence suggests an interaction between the two in brain regions 
      pertinent to schizophrenia. This review will focus on the role of estrogen and 
      BDNF in clinical and animal studies of schizophrenia. We include animal models of 
      neurotransmitter dysfunction and genetic manipulation to show how estrogen may 
      provide a protective effect in schizophrenia, including through mediating BDNF 
      expression and activity. This posited estrogen-BDNF interaction could play a key 
      role in modulating sex-dependent results reported in animal work as well as sex 
      differences in clinical aspects of schizophrenia.
CI  - Copyright (c) 2012 IBRO. Published by Elsevier Ltd. All rights reserved.
FAU - Wu, Y C
AU  - Wu YC
AD  - Behavioural Neuroscience Laboratory, Mental Health Research Institute, Parkville, 
      Melbourne, Australia.
FAU - Hill, R A
AU  - Hill RA
FAU - Gogos, A
AU  - Gogos A
FAU - van den Buuse, M
AU  - van den Buuse M
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20121022
PL  - United States
TA  - Neuroscience
JT  - Neuroscience
JID - 7605074
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Estrogens)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Disease Models, Animal
MH  - Estrogens/*metabolism
MH  - Female
MH  - Humans
MH  - Male
MH  - Schizophrenia/*metabolism
MH  - *Sex Characteristics
EDAT- 2012/10/23 06:00
MHDA- 2013/10/18 06:00
CRDT- 2012/10/23 06:00
PHST- 2012/07/27 00:00 [received]
PHST- 2012/10/08 00:00 [revised]
PHST- 2012/10/09 00:00 [accepted]
PHST- 2012/10/23 06:00 [entrez]
PHST- 2012/10/23 06:00 [pubmed]
PHST- 2013/10/18 06:00 [medline]
AID - S0306-4522(12)01032-9 [pii]
AID - 10.1016/j.neuroscience.2012.10.024 [doi]
PST - ppublish
SO  - Neuroscience. 2013 Jun 3;239:67-83. doi: 10.1016/j.neuroscience.2012.10.024. Epub 
      2012 Oct 22.