PMID- 23085478
OWN - NLM
STAT- MEDLINE
DCOM- 20130517
LR  - 20151119
IS  - 1872-7549 (Electronic)
IS  - 0166-4328 (Linking)
VI  - 238
DP  - 2013 Feb 1
TI  - Tetrandrine exerts antidepressant-like effects in animal models: role of 
      brain-derived neurotrophic factor.
PG  - 79-85
LID - S0166-4328(12)00662-6 [pii]
LID - 10.1016/j.bbr.2012.10.015 [doi]
AB  - The present study focused on investigating the antidepressant potential of 
      tetrandrine and its possible mechanisms of action. Forced swimming test (FST) and 
      tail suspension test (TST) were used to reveal the antidepressant-like effect of 
      tetrandrine. Potential mechanisms were explored applying reserpine-induced ptosis 
      and hypothermia in mice, as well as using the chronic unpredictable mild stress 
      (CUMS) induced depression model in rats. Tetrandrine reduced immobility time in 
      both the FST and TST and antagonized reserpine-induced ptosis and hypothermia in 
      mice. The concentrations of 5-hydroxytryptamine (5-HT) and norepinephrine (NE) in 
      mice hippocampi decreased after the administration of reserpine. However, 
      pre-treatments with tetrandrine significantly increased the concentrations of 
      5-HT and NE in mice hippocampi. In the CUMS-induced depressive rats, bodyweight, 
      1% sucrose consumption and the concentrations of 5-HT and NE in hippocampi 
      decreased significantly compared with the normal control group. However, these 
      changes could be significantly reversed by tetrandrine application. Furthermore, 
      the levels of the brain-derived neurotrophic factor (BDNF) in hippocampi 
      increased in the tetrandrine-treated rats exposed to CUMS. In summary, our 
      findings suggest that the antidepressant-like effect of tetrandrine is involved 
      in the regulation of the central monoaminergic neurotransmitter system and the 
      levels of BDNF.
CI  - Copyright (c) 2012 Elsevier B.V. All rights reserved.
FAU - Gao, Shan
AU  - Gao S
AD  - Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of 
      Traditional Chinese Medicine, Tianjin, PR China.
FAU - Cui, Yuan-Lu
AU  - Cui YL
FAU - Yu, Chun-Quan
AU  - Yu CQ
FAU - Wang, Qiang-Song
AU  - Wang QS
FAU - Zhang, Ye
AU  - Zhang Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121022
PL  - Netherlands
TA  - Behav Brain Res
JT  - Behavioural brain research
JID - 8004872
RN  - 0 (Antidepressive Agents)
RN  - 0 (Benzylisoquinolines)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 29EX23D5AJ (tetrandrine)
RN  - 333DO1RDJY (Serotonin)
RN  - X4W3ENH1CV (Norepinephrine)
SB  - IM
MH  - Animals
MH  - Antidepressive Agents/pharmacology/*therapeutic use
MH  - Behavior, Animal/*drug effects
MH  - Benzylisoquinolines/pharmacology/*therapeutic use
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Depressive Disorder/*drug therapy/metabolism
MH  - Disease Models, Animal
MH  - Hindlimb Suspension
MH  - Hippocampus/drug effects/metabolism
MH  - Male
MH  - Mice
MH  - Mice, Inbred ICR
MH  - Motor Activity/drug effects
MH  - Norepinephrine/metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Serotonin/metabolism
MH  - Stress, Psychological/drug therapy/metabolism
MH  - Swimming
EDAT- 2012/10/23 06:00
MHDA- 2013/05/18 06:00
CRDT- 2012/10/23 06:00
PHST- 2012/03/03 00:00 [received]
PHST- 2012/10/07 00:00 [revised]
PHST- 2012/10/11 00:00 [accepted]
PHST- 2012/10/23 06:00 [entrez]
PHST- 2012/10/23 06:00 [pubmed]
PHST- 2013/05/18 06:00 [medline]
AID - S0166-4328(12)00662-6 [pii]
AID - 10.1016/j.bbr.2012.10.015 [doi]
PST - ppublish
SO  - Behav Brain Res. 2013 Feb 1;238:79-85. doi: 10.1016/j.bbr.2012.10.015. Epub 2012 
      Oct 22.