PMID- 23085522
OWN - NLM
STAT- MEDLINE
DCOM- 20130709
LR  - 20151119
IS  - 1872-9711 (Electronic)
IS  - 0161-813X (Linking)
VI  - 34
DP  - 2013 Jan
TI  - Evaluating the neurotoxic effects of lactational exposure to persistent organic 
      pollutants (POPs) in Spanish children.
PG  - 9-15
LID - S0161-813X(12)00249-5 [pii]
LID - 10.1016/j.neuro.2012.10.006 [doi]
AB  - Although the brain continues developing in the postnatal period, epidemiological 
      studies on the effects of postnatal exposure to neurotoxic POPs through 
      breast-feeding remain mostly inconclusive. Failure to detect associations between 
      postnatal exposure and health outcomes may stem from the limitations of commonly 
      employed approaches to assess lactational exposure. The aim of the present study 
      was to assess whether lactational exposure to polychlorinated biphenyl-153 
      (PCB-153), dichlorodiphenyldichloroethylene (DDE), or hexachlorobenzene (HCB) as 
      estimated with a physiologically based pharmacokinetic (PBPK) model, is 
      associated with decrements in mental and psychomotor development scores of the 
      Bayley Scales of Infant Development (BSID) test in children aged around 14-months 
      of a subsample (N=1175) of the Spanish INMA birth cohort, and to compare this 
      with the effects of prenatal exposure. Although in the present study population 
      PCB-153, DDE and HCB exposure increased within the first months of postnatal 
      life, no associations were found between different periods of postnatal exposure 
      to these compounds and mental or psychomotor scores. Increasing prenatal PCB-153 
      concentrations were associated with worse mental and psychomotor scores, although 
      significance was only reached for psychomotor development (beta [95%CI]=-1.36 
      [-2.61, -0.11]). Indeed, the association between exposure and effects observed 
      during prenatal life weakened gradually across periods of postnatal life. Results 
      of the present study suggest that, although breastfeeding increases children's 
      blood persistent organic pollutants (POPs) levels during postnatal life, 
      deleterious effects of PCB-153 on neuropsychological development are mainly 
      attributable to prenatal exposure.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Gascon, Mireia
AU  - Gascon M
AD  - Centre for Research in Environmental Epidemiology, Dr. Aiguader 88, 08003 
      Barcelona, Catalonia, Spain. mgascon@creal.cat
FAU - Verner, Marc-Andre
AU  - Verner MA
FAU - Guxens, Monica
AU  - Guxens M
FAU - Grimalt, Joan O
AU  - Grimalt JO
FAU - Forns, Joan
AU  - Forns J
FAU - Ibarluzea, Jesus
AU  - Ibarluzea J
FAU - Lertxundi, Nerea
AU  - Lertxundi N
FAU - Ballester, Ferran
AU  - Ballester F
FAU - Llop, Sabrina
AU  - Llop S
FAU - Haddad, Sami
AU  - Haddad S
FAU - Sunyer, Jordi
AU  - Sunyer J
FAU - Vrijheid, Martine
AU  - Vrijheid M
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20121018
PL  - Netherlands
TA  - Neurotoxicology
JT  - Neurotoxicology
JID - 7905589
RN  - 0 (Environmental Pollutants)
RN  - 4M7FS82U08 (Dichlorodiphenyl Dichloroethylene)
RN  - 4Z87H0LKUY (Hexachlorobenzene)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
RN  - ZRU0C9E32O (2,4,5,2',4',5'-hexachlorobiphenyl)
SB  - IM
MH  - Age Factors
MH  - Brain/*drug effects/growth & development/metabolism/physiopathology
MH  - Breast Feeding/*adverse effects
MH  - Child Development/drug effects
MH  - Cognition/drug effects
MH  - Dichlorodiphenyl Dichloroethylene/*adverse effects/blood/pharmacokinetics
MH  - Environmental Pollutants/*adverse effects
MH  - Female
MH  - Hexachlorobenzene/*adverse effects/blood/pharmacokinetics
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - *Lactation
MH  - Linear Models
MH  - Maternal Exposure/adverse effects
MH  - Milk, Human/*metabolism
MH  - Models, Biological
MH  - Neuropsychological Tests
MH  - Neurotoxicity Syndromes/blood/*etiology/physiopathology/psychology
MH  - Polychlorinated Biphenyls/*adverse effects/blood/pharmacokinetics
MH  - Pregnancy
MH  - Prenatal Exposure Delayed Effects
MH  - Psychomotor Performance/drug effects
MH  - Risk Assessment
MH  - Risk Factors
MH  - Spain
EDAT- 2012/10/23 06:00
MHDA- 2013/07/10 06:00
CRDT- 2012/10/23 06:00
PHST- 2012/07/23 00:00 [received]
PHST- 2012/09/17 00:00 [revised]
PHST- 2012/10/09 00:00 [accepted]
PHST- 2012/10/23 06:00 [entrez]
PHST- 2012/10/23 06:00 [pubmed]
PHST- 2013/07/10 06:00 [medline]
AID - S0161-813X(12)00249-5 [pii]
AID - 10.1016/j.neuro.2012.10.006 [doi]
PST - ppublish
SO  - Neurotoxicology. 2013 Jan;34:9-15. doi: 10.1016/j.neuro.2012.10.006. Epub 2012 
      Oct 18.