PMID- 23085747
OWN - NLM
STAT- MEDLINE
DCOM- 20131021
LR  - 20211021
IS  - 1438-8359 (Electronic)
IS  - 0913-8668 (Linking)
VI  - 27
IP  - 2
DP  - 2013 Apr
TI  - Changes in plasma and cerebrospinal fluid biomarkers in aged patients with early 
      postoperative cognitive dysfunction following total hip-replacement surgery.
PG  - 236-42
LID - 10.1007/s00540-012-1506-3 [doi]
AB  - PURPOSE: We hypothesized that different patterns of biomarkers of brain injury 
      and inflammation exist in aged patients with postoperative cognitive dysfunction 
      (POCD) after total hip-replacement with spinal anesthesia. METHODS: Eighty-three 
      patients older than 65 years undergoing elective total hip-replacement surgery 
      were enrolled in this prospective observational study. The CSF levels of Tau, 
      phosphorylated-tau (pTau), amyloidbeta1-42 (Abeta1-42), Tau/Abeta1-42, pTau/Abeta1-42, BDNF, 
      IL-6, and IL-1beta were measured preoperatively. Perioperative plasma levels of 
      IL-1beta, IL-6, brain-derived neurotrophic factor (BDNF), C-reactive protein (CRP), 
      and malonaldehyde (MDA) as well as neurocognitive tests were determined 
      preoperatively and seven days postoperatively. RESULTS: Sixty-one patients 
      completed both the CSF and blood samples collection and the neurocognitive tests. 
      POCD occurred in 24.6 % of patients at seven days after surgery. Patients with 
      POCD had significantly higher IL-1beta, Tau/Abeta1-42, pTau/Abeta1-42, and a lower level 
      of Abeta1-42 in CSF when compared with the Non-POCD group (P < 0.05). Furthermore, 
      POCD patients displayed significantly higher plasma levels of MDA when compared 
      with Non-POCD patients at seven days after surgery (P < 0.05). There was no 
      difference in preoperative CSF levels of Tau, IL-6, and pTau as well as plasma 
      levels of IL-1beta, IL-6, BDNF and CRP between POCD and Non-POCD groups (P > 0.05). 
      CONCLUSION: The POCD patients were associated with higher postoperative plasma 
      levels of MDA, and higher IL-1beta and lower Abeta1-42 levels in preoperative CSF that 
      might predispose the development of POCD in aged patients following total 
      hip-replacement surgery with spinal anesthesia.
FAU - Ji, Mu-Huo
AU  - Ji MH
AD  - Department of Anesthesiology, Jinling Hospital, School of Medicine, Nanjing 
      University, 305 East Zhongshan Road, Nanjing 210002, China.
FAU - Yuan, Hong-Mei
AU  - Yuan HM
FAU - Zhang, Guang-Fen
AU  - Zhang GF
FAU - Li, Xiao-Min
AU  - Li XM
FAU - Dong, Lin
AU  - Dong L
FAU - Li, Wei-Yan
AU  - Li WY
FAU - Zhou, Zhi-Qiang
AU  - Zhou ZQ
FAU - Yang, Jian-Jun
AU  - Yang JJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121022
PL  - Japan
TA  - J Anesth
JT  - Journal of anesthesia
JID - 8905667
RN  - 0 (Amyloid beta-Peptides)
RN  - 0 (Biomarkers)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Inflammation Mediators)
RN  - 0 (Interleukin-6)
RN  - 0 (Peptide Fragments)
RN  - 0 (amyloid beta-protein (1-42))
RN  - 0 (tau Proteins)
RN  - 4Y8F71G49Q (Malondialdehyde)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Amyloid beta-Peptides/blood/cerebrospinal fluid
MH  - Anesthesia, Spinal
MH  - Arthroplasty, Replacement, Hip/*adverse effects
MH  - Biomarkers/*blood/*cerebrospinal fluid
MH  - Brain-Derived Neurotrophic Factor/blood/cerebrospinal fluid
MH  - C-Reactive Protein/cerebrospinal fluid
MH  - Cognition Disorders/*blood/*cerebrospinal fluid/psychology
MH  - Female
MH  - Humans
MH  - Inflammation Mediators/blood/cerebrospinal fluid
MH  - Interleukin-6/blood/cerebrospinal fluid
MH  - Male
MH  - Malondialdehyde/blood/cerebrospinal fluid
MH  - Neuropsychological Tests
MH  - Pain, Postoperative/drug therapy
MH  - Peptide Fragments/blood/cerebrospinal fluid
MH  - Postoperative Complications/*blood/*cerebrospinal fluid/psychology
MH  - Predictive Value of Tests
MH  - Psychomotor Performance/physiology
MH  - tau Proteins/blood/cerebrospinal fluid
EDAT- 2012/10/23 06:00
MHDA- 2013/10/22 06:00
CRDT- 2012/10/23 06:00
PHST- 2012/07/23 00:00 [received]
PHST- 2012/10/09 00:00 [accepted]
PHST- 2012/10/23 06:00 [entrez]
PHST- 2012/10/23 06:00 [pubmed]
PHST- 2013/10/22 06:00 [medline]
AID - 10.1007/s00540-012-1506-3 [doi]
PST - ppublish
SO  - J Anesth. 2013 Apr;27(2):236-42. doi: 10.1007/s00540-012-1506-3. Epub 2012 Oct 
      22.