PMID- 23085892
OWN - NLM
STAT- MEDLINE
DCOM- 20130917
LR  - 20151119
IS  - 1536-4801 (Electronic)
IS  - 0277-2116 (Linking)
VI  - 56
IP  - 4
DP  - 2013 Apr
TI  - Human leukocyte antigen DQ2.2 and celiac disease.
PG  - 428-30
LID - 10.1097/MPG.0b013e31827913f9 [doi]
AB  - Patients with celiac disease (CD) lacking both human leukocyte antigen 
      (HLA)-DQ2.5 in cis (DQA1*05:01, DQB1*02:01) or trans (DQA1*05:05, DQB1*02:02) 
      configuration and HLA-DQ8 (DQA1*03:01, DQB1*03:02) are considered to be rare. 
      Therefore, absence of these genotypes is commonly used to exclude the diagnosis 
      of CD. To investigate whether this approach is justified, the HLA-distribution in 
      155 children with CD was studied. A total of 139 (89.7%) patients carried 
      HLA-DQ2.5. Of the remaining patients, 7 (4.5%) carried HLA-DQ8. Interestingly, 
      the 9 (5.8%) patients lacking HLA-DQ2.5 and HLA-DQ8 carried HLA-DQA1*02:01 and 
      -DQB1*02:02 (HLA-DQ2.2). Therefore, HLA-DQ2.2 should be included as an important 
      HLA-type related to CD.
FAU - Mubarak, Amani
AU  - Mubarak A
AD  - Department of Pediatric Gastroenterology, University Medical Center Utrecht, 
      Utrecht, The Netherlands. A.Mubarak@umcutrecht.nl
FAU - Spierings, Eric
AU  - Spierings E
FAU - Wolters, Victorien
AU  - Wolters V
FAU - van Hoogstraten, Ingrid
AU  - van Hoogstraten I
FAU - Kneepkens, C M Frank
AU  - Kneepkens CM
FAU - Houwen, Roderick
AU  - Houwen R
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Pediatr Gastroenterol Nutr
JT  - Journal of pediatric gastroenterology and nutrition
JID - 8211545
RN  - 0 (Biomarkers)
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ alpha-Chains)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQ2 antigen)
RN  - 0 (HLA-DQ8 antigen)
RN  - 0 (HLA-DQA1 antigen)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (Protein Isoforms)
SB  - IM
MH  - Alleles
MH  - Biomarkers/blood/metabolism
MH  - Celiac Disease/diagnosis/genetics/immunology/*metabolism
MH  - Child
MH  - Cohort Studies
MH  - Exons
MH  - Female
MH  - Genetic Association Studies
MH  - Genetic Predisposition to Disease
MH  - HLA-DQ Antigens/blood/genetics/*metabolism
MH  - HLA-DQ alpha-Chains/blood/genetics/*metabolism
MH  - HLA-DQ beta-Chains/blood/genetics/*metabolism
MH  - Humans
MH  - Leukocytes/immunology/*metabolism
MH  - Male
MH  - Netherlands
MH  - Prospective Studies
MH  - Protein Isoforms/blood/genetics/metabolism
MH  - Retrospective Studies
EDAT- 2012/10/23 06:00
MHDA- 2013/09/18 06:00
CRDT- 2012/10/23 06:00
PHST- 2012/10/23 06:00 [entrez]
PHST- 2012/10/23 06:00 [pubmed]
PHST- 2013/09/18 06:00 [medline]
AID - 10.1097/MPG.0b013e31827913f9 [doi]
PST - ppublish
SO  - J Pediatr Gastroenterol Nutr. 2013 Apr;56(4):428-30. doi: 
      10.1097/MPG.0b013e31827913f9.