PMID- 23086097
OWN - NLM
STAT- MEDLINE
DCOM- 20140821
LR  - 20211021
IS  - 2154-8331 (Print)
IS  - 2154-8331 (Linking)
VI  - 40
IP  - 3
DP  - 2012 Aug
TI  - Pancreatectomy and autologous islet transplantation for painful chronic 
      pancreatitis: indications and outcomes.
PG  - 80-7
LID - 10.3810/hp.2012.08.992 [doi]
AB  - Total pancreatectomy with intrahepatic autoislet transplantation (TP/IAT) is a 
      definitive treatment for relentlessly painful chronic pancreatitis. Pain relief 
      is reported to be achieved in approximately 80% of patients. Overall, 30% to 40% 
      achieve insulin independence, and 70% of recipients remain insulin independent 
      for > 2 years, sometimes longer if > 300 000 islets are successfully 
      transplanted. Yet, this approach to chronic pancreatitis is underemphasized in 
      the general medical and surgical literature and vastly underused in the United 
      States. This review emphasizes the history and metabolic outcomes of TP/IAT and 
      considers its usefulness in the context of other, more frequently used 
      approaches, such as operative intervention with partial pancreatectomy and/or 
      lateral pancreaticojejunostomy (Puestow procedure), as well as endoscopic 
      retrograde cholangiopancreatography with pancreatic duct modification and stent 
      placement. Distal pancreatectomy and Puestow procedures compromise isolation of 
      islet mass, and adversely affect islet autotransplant outcomes. Therefore, when 
      endoscopic measures fail to relieve pain in severe chronic pancreatitis, we 
      recommend early intervention with TP/IAT.
FAU - Bellin, Melena D
AU  - Bellin MD
AD  - The Division of Endocrinology, Department of Pediatrics, University of Minnesota, 
      St. Paul, MN.
FAU - Sutherland, David E R
AU  - Sutherland DE
FAU - Robertson, R Paul
AU  - Robertson RP
LA  - eng
GR  - K23 DK084315/DK/NIDDK NIH HHS/United States
GR  - R01 39994/PHS HHS/United States
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
PL  - England
TA  - Hosp Pract (1995)
JT  - Hospital practice (1995)
JID - 101268948
SB  - IM
MH  - Adult
MH  - Female
MH  - Humans
MH  - Islets of Langerhans Transplantation/*methods
MH  - Pain Management
MH  - Pancreatectomy/*methods
MH  - Pancreatitis, Chronic/*surgery
MH  - Quality of Life
EDAT- 2012/10/23 06:00
MHDA- 2014/08/22 06:00
CRDT- 2012/10/23 06:00
PHST- 2012/10/23 06:00 [entrez]
PHST- 2012/10/23 06:00 [pubmed]
PHST- 2014/08/22 06:00 [medline]
AID - 10.3810/hp.2012.08.992 [doi]
PST - ppublish
SO  - Hosp Pract (1995). 2012 Aug;40(3):80-7. doi: 10.3810/hp.2012.08.992.