PMID- 23086694
OWN - NLM
STAT- MEDLINE
DCOM- 20130708
LR  - 20240418
IS  - 1552-9924 (Electronic)
IS  - 0091-6765 (Print)
IS  - 0091-6765 (Linking)
VI  - 121
IP  - 1
DP  - 2013 Jan
TI  - Toxicokinetic modeling of persistent organic pollutant levels in blood from birth 
      to 45 months of age in longitudinal birth cohort studies.
PG  - 131-7
LID - 10.1289/ehp.1205552 [doi]
AB  - BACKGROUND: Despite experimental evidence that lactational exposure to persistent 
      organic pollutants (POPs) can impact health, results from epidemiologic studies 
      are inconclusive. Inconsistency across studies may reflect the inability of 
      current methods to estimate children's blood levels during specific periods of 
      susceptibility. OBJECTIVES: We developed a toxicokinetic model to simulate blood 
      POP levels in children from two longitudinal birth cohorts and aimed to validate 
      it against blood levels measured at 6, 16, and 45 months of age. METHODS: The 
      model consisted of a maternal and a child lipid compartment connected through 
      placental diffusion and breastfeeding. Simulations were carried out based on 
      individual physiologic parameters; duration of breastfeeding; and levels of POPs 
      measured in maternal blood at delivery, cord blood, or breast milk. Model 
      validity was assessed through regression analyses of simulated against measured 
      blood levels. RESULTS: Simulated levels explained between 10% and 83% of measured 
      blood levels depending on the cohort, the compound, the sample used to simulate 
      children's blood levels, and child's age when blood levels were measured. Model 
      accuracy was highest for estimated blood POP levels at 6 months based on maternal 
      or cord blood levels. However, loss in model precision between the 6th and the 
      45th month was small for most compounds. CONCLUSIONS: Our validated toxicokinetic 
      model can be used to estimate children's blood POP levels in early to 
      mid-childhood. Estimates can be used in epidemiologic studies to evaluate the 
      impact of exposure during hypothesized postnatal periods of susceptibility on 
      health.
FAU - Verner, Marc-Andre
AU  - Verner MA
AD  - Institute of Environmental Medicine, Karolinska Institutet, Solna, Sweden. 
      marcandre.verner@channing.harvard.edu
FAU - Sonneborn, Dean
AU  - Sonneborn D
FAU - Lancz, Kinga
AU  - Lancz K
FAU - Muckle, Gina
AU  - Muckle G
FAU - Ayotte, Pierre
AU  - Ayotte P
FAU - Dewailly, Eric
AU  - Dewailly E
FAU - Kocan, Anton
AU  - Kocan A
FAU - Palkovicova, Lubica
AU  - Palkovicova L
FAU - Trnovec, Tomas
AU  - Trnovec T
FAU - Haddad, Sami
AU  - Haddad S
FAU - Hertz-Picciotto, Irva
AU  - Hertz-Picciotto I
FAU - Eggesbo, Merete
AU  - Eggesbo M
LA  - eng
GR  - R01-CA096525/CA/NCI NIH HHS/United States
GR  - R01-ES015359/ES/NIEHS NIH HHS/United States
GR  - P01 ES011269/ES/NIEHS NIH HHS/United States
GR  - R01 ES020392/ES/NIEHS NIH HHS/United States
GR  - R01 ES015359/ES/NIEHS NIH HHS/United States
GR  - R01 ES007902/ES/NIEHS NIH HHS/United States
GR  - R01-ES007902/ES/NIEHS NIH HHS/United States
GR  - P01-ES011269/ES/NIEHS NIH HHS/United States
GR  - R01 CA096525/CA/NCI NIH HHS/United States
GR  - R01-ES020392/ES/NIEHS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20121017
PL  - United States
TA  - Environ Health Perspect
JT  - Environmental health perspectives
JID - 0330411
RN  - 0 (Environmental Pollutants)
SB  - IM
MH  - Child, Preschool
MH  - Cohort Studies
MH  - Environmental Pollutants/*toxicity
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Lactation
MH  - Longitudinal Studies
MH  - Milk, Human
MH  - *Models, Theoretical
PMC - PMC3553439
COIS- The authors declare they have no actual or potential competing financial 
      interests.
EDAT- 2012/10/23 06:00
MHDA- 2013/07/09 06:00
PMCR- 2013/01/01
CRDT- 2012/10/23 06:00
PHST- 2012/06/01 00:00 [received]
PHST- 2012/10/17 00:00 [accepted]
PHST- 2012/10/23 06:00 [entrez]
PHST- 2012/10/23 06:00 [pubmed]
PHST- 2013/07/09 06:00 [medline]
PHST- 2013/01/01 00:00 [pmc-release]
AID - ehp.1205552 [pii]
AID - 10.1289/ehp.1205552 [doi]
PST - ppublish
SO  - Environ Health Perspect. 2013 Jan;121(1):131-7. doi: 10.1289/ehp.1205552. Epub 
      2012 Oct 17.