PMID- 23087256
OWN - NLM
STAT- MEDLINE
DCOM- 20140328
LR  - 20220330
IS  - 1752-8976 (Electronic)
IS  - 1470-3203 (Linking)
VI  - 14
IP  - 2
DP  - 2013 Jun
TI  - Neuropathic pain-attenuating potential of aliskiren in chronic constriction 
      injury model in rats.
PG  - 116-23
LID - 10.1177/1470320312460899 [doi]
AB  - The present study was designed to investigate the potential of aliskiren, a 
      direct renin inhibitor, in chronic constriction injury (CCI)-induced neuropathic 
      pain in rats. Neuropathic pain was induced by placing four loose ligatures around 
      the sciatic nerve. Acetone drop, von Frey hair, pin-prick and hot plate tests 
      were performed to assess cold allodynia, mechanical allodynia, mechanical and 
      heat hyperalgesia, respectively. The levels of Tumor necrosis factor-alpha 
      (TNF-alpha) were measured in the sciatic nerve as an inflammatory marker. CCI was 
      associated with the development of cold allodynia, mechanical allodynia, 
      mechanical and heat hyperalgesia along with a rise in the levels of Tumor 
      necrosis factor-alpha (TNF-alpha). Administration of aliskiren (25 or 50 mg/kg 
      intraperitoneal (i.p.)) for 14 days in CCI-subjected rats significantly 
      attenuated CCI-induced pain-related behavior and rise in TNF-alpha level. It may be 
      concluded that aliskiren-mediated anti-inflammatory actions may be responsible 
      for its beneficial effects in neuropathic pain in rats.
FAU - Kukkar, Ankesh
AU  - Kukkar A
AD  - Department of Pharmaceutical Sciences and Drug Research, Punjabi University, 
      India.
FAU - Singh, Nirmal
AU  - Singh N
FAU - Jaggi, Amteshwar S
AU  - Jaggi AS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121019
PL  - England
TA  - J Renin Angiotensin Aldosterone Syst
JT  - Journal of the renin-angiotensin-aldosterone system : JRAAS
JID - 100971636
RN  - 0 (Amides)
RN  - 0 (Fumarates)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 502FWN4Q32 (aliskiren)
SB  - IM
MH  - Amides/pharmacology/*therapeutic use
MH  - Animals
MH  - Constriction
MH  - Disease Models, Animal
MH  - Female
MH  - Fumarates/pharmacology/*therapeutic use
MH  - Hyperalgesia/complications/drug therapy
MH  - Male
MH  - Neuralgia/complications/*drug therapy
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Sciatic Nerve/drug effects/*injuries/pathology
MH  - Tumor Necrosis Factor-alpha/metabolism
OTO - NOTNLM
OT  - Chronic constriction injury
OT  - aliskiren
OT  - inflammation
OT  - neuropathic pain
OT  - sciatic nerve ligation
EDAT- 2012/10/23 06:00
MHDA- 2014/03/29 06:00
CRDT- 2012/10/23 06:00
PHST- 2012/10/23 06:00 [entrez]
PHST- 2012/10/23 06:00 [pubmed]
PHST- 2014/03/29 06:00 [medline]
AID - 1470320312460899 [pii]
AID - 10.1177/1470320312460899 [doi]
PST - ppublish
SO  - J Renin Angiotensin Aldosterone Syst. 2013 Jun;14(2):116-23. doi: 
      10.1177/1470320312460899. Epub 2012 Oct 19.