PMID- 23087561
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121023
LR  - 20211021
IS  - 1998-3662 (Electronic)
IS  - 0971-4065 (Print)
IS  - 0971-4065 (Linking)
VI  - 22
IP  - 3
DP  - 2012 May
TI  - Light chain deposition disease in a postrenal transplant patient.
PG  - 221-3
LID - 10.4103/0971-4065.98768 [doi]
AB  - The morphological spectrum of light chain deposition disease (LCDD) may range 
      from normal glomerular morphology to mesangio-proliferative to mesangio-capillary 
      to nodular sclerosing patterns. Due to the inconsistencies regarding treatment 
      and the universally poor graft outcome of post-transplant LCDD, it is imperative 
      to maintain a high index of suspicion and perform relevant investigations for 
      clinching this diagnosis. A 40-year-old lady was diagnosed as a case of 
      membrano-proliferative glomerulonephritis 3 years back, for which she underwent a 
      live unrelated renal allograft transplant. Postoperative period was complicated 
      by an acute rise in serum creatinine on the 21(st) postoperative day. Biopsy 
      showed patchy acute cortical necrosis, which responded to conservative 
      management. The present admission was for renal failure and subnephrotic 
      proteinuria. A kidney biopsy was performed, and all the 14 glomeruli examined 
      showed a mesangiocapillary pattern of glomerular injury with cellular nodule 
      formation in some. The nodules were PAS and Congo red negative. 
      Immunofluorescence showed glomerular and tubular basement staining for Kappa 
      light chains only. Electron microscopy showed the characteristic granular 
      deposits in subendothelial location in the glomerulus, and in tubular basement 
      membranes, thus confirming the diagnosis of LCDD. Membranoproliferative pattern 
      of glomerular injury in the pre- and posttransplant setting has a wide range of 
      differential diagnoses; LCDD being one of them.
FAU - Mittal, N
AU  - Mittal N
AD  - Department of Histopathology, Renal Transplant Surgery, PGIMER, Chandigarh, 
      India.
FAU - Bansal, R
AU  - Bansal R
FAU - Nada, R
AU  - Nada R
FAU - Minz, R
AU  - Minz R
FAU - Minz, M
AU  - Minz M
FAU - Joshi, K
AU  - Joshi K
LA  - eng
PT  - Case Reports
PL  - India
TA  - Indian J Nephrol
JT  - Indian journal of nephrology
JID - 8914356
PMC - PMC3459530
OTO - NOTNLM
OT  - Light chain deposition disease
OT  - glomerulus
OT  - postrenal transplant kidney
COIS- Conflict of Interest: None declared.
EDAT- 2012/10/23 06:00
MHDA- 2012/10/23 06:01
PMCR- 2012/05/01
CRDT- 2012/10/23 06:00
PHST- 2012/10/23 06:00 [entrez]
PHST- 2012/10/23 06:00 [pubmed]
PHST- 2012/10/23 06:01 [medline]
PHST- 2012/05/01 00:00 [pmc-release]
AID - IJN-22-221 [pii]
AID - 10.4103/0971-4065.98768 [doi]
PST - ppublish
SO  - Indian J Nephrol. 2012 May;22(3):221-3. doi: 10.4103/0971-4065.98768.