PMID- 23087644
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121023
LR  - 20211021
IS  - 1663-9812 (Electronic)
IS  - 1663-9812 (Linking)
VI  - 3
DP  - 2012
TI  - Associations of Cigarette Smoking and Polymorphisms in Brain-Derived Neurotrophic 
      Factor and Catechol-O-Methyltransferase with Neurocognition in Alcohol Dependent 
      Individuals during Early Abstinence.
PG  - 178
LID - 10.3389/fphar.2012.00178 [doi]
LID - 178
AB  - Chronic cigarette smoking and polymorphisms in brain-derived neurotrophic factor 
      (BDNF) and catechol-O-methyltransferase (COMT) are associated with neurocognition 
      in normal controls and those with various neuropsychiatric conditions. The 
      influence of BDNF and COMT on neurocognition in alcohol dependence is unclear. 
      The primary goal of this report was to investigate the associations of single 
      nucleotide polymorphisms (SNPs) in BDNF Val66Met (rs6265) and COMT Val158Met 
      (rs4680) with neurocognition in a treatment-seeking alcohol dependent cohort and 
      determine if neurocognitive differences between non-smokers and smokers 
      previously observed in this cohort persist when controlled for these functional 
      SNPs. Genotyping was conducted on 70 primarily male treatment-seeking alcohol 
      dependent participants (ALC) who completed a comprehensive neuropsychological 
      battery after 33 +/- 9 days of monitored abstinence. After controlling for COMT and 
      BDNF genotypes, smoking ALC performed significantly worse than non-smoking ALC on 
      the domains of auditory-verbal and visuospatial learning and memory, cognitive 
      efficiency, general intelligence, processing speed, and global neurocognition. In 
      smoking ALC, greater number of years of smoking over lifetime was related to 
      poorer performance on multiple domains after controlling for genotypes and 
      alcohol consumption. In addition, COMT Met homozygotes were superior to Val 
      homozygotes on measures of executive skills and showed trends for higher general 
      intelligence and visuospatial skills, while COMT Val/Met heterozygotes showed 
      significantly better general intelligence than Val homozygotes. COMT Val 
      homozygotes performed better than heterozygotes on auditory-verbal memory. BDNF 
      genotype was not related to any neurocognitive domain. The findings are 
      consistent with studies in normal controls and neuropsychiatric cohorts that 
      reported COMT Met carriers demonstrated better performance on measures of 
      executive skills and general intelligence. Results also indicated that the poorer 
      performance of smoking compared to non-smoking ALC across multiple neurocognitive 
      domains was not mediated by COMT or BDNF genotype. Overall, the findings lend 
      support to the expanding clinical movement to make smoking cessation programs 
      available to smokers at the inception of treatment for alcohol/substance use 
      disorders.
FAU - Durazzo, Timothy C
AU  - Durazzo TC
AD  - Center for Imaging of Neurodegenerative Diseases, San Francisco VA Medical Center 
      San Francisco, CA, USA ; Department of Radiology and Biomedical Imaging, 
      University of California San Francisco, CA, USA.
FAU - Hutchison, Kent E
AU  - Hutchison KE
FAU - Fryer, Susanna L
AU  - Fryer SL
FAU - Mon, Anderson
AU  - Mon A
FAU - Meyerhoff, Dieter J
AU  - Meyerhoff DJ
LA  - eng
GR  - K01 DA024136/DA/NIDA NIH HHS/United States
GR  - R01 AA010788/AA/NIAAA NIH HHS/United States
GR  - R01 AA012238/AA/NIAAA NIH HHS/United States
GR  - R29 AA012238/AA/NIAAA NIH HHS/United States
PT  - Journal Article
DEP - 20121011
PL  - Switzerland
TA  - Front Pharmacol
JT  - Frontiers in pharmacology
JID - 101548923
PMC - PMC3469037
OTO - NOTNLM
OT  - alcohol dependence
OT  - brain-derived neurotrophic factor
OT  - catechol-O-methyltransferase
OT  - cigarette smoking
OT  - neurocognition
EDAT- 2012/10/23 06:00
MHDA- 2012/10/23 06:01
PMCR- 2012/10/11
CRDT- 2012/10/23 06:00
PHST- 2012/07/17 00:00 [received]
PHST- 2012/09/16 00:00 [accepted]
PHST- 2012/10/23 06:00 [entrez]
PHST- 2012/10/23 06:00 [pubmed]
PHST- 2012/10/23 06:01 [medline]
PHST- 2012/10/11 00:00 [pmc-release]
AID - 10.3389/fphar.2012.00178 [doi]
PST - epublish
SO  - Front Pharmacol. 2012 Oct 11;3:178. doi: 10.3389/fphar.2012.00178. eCollection 
      2012.