PMID- 23088744
OWN - NLM
STAT- MEDLINE
DCOM- 20131209
LR  - 20211021
IS  - 1029-2403 (Electronic)
IS  - 1026-8022 (Linking)
VI  - 54
IP  - 6
DP  - 2013 Jun
TI  - Immune reconstitution after combined haploidentical and umbilical cord blood 
      transplant.
PG  - 1242-9
LID - 10.3109/10428194.2012.739688 [doi]
AB  - Umbilical cord blood (UCB) stem cells are frequently employed for allogeneic stem 
      cell transplant, but delayed myeloid and lymphoid immune reconstitution leads to 
      increased risk of infections. We recently reported the clinical results of 45 
      patients enrolled on a pilot study combining UCB with a human leukocyte antigen 
      (HLA)-haploidentical donor with reduced-intensity conditioning who showed rapid 
      neutrophil and platelet recovery. We report here preliminary immune 
      reconstitution data of these patients. Patients were assessed for lymphocyte 
      subsets, T-cell diversity, Cylex ImmuKnow assay and serological response to 
      pneumococcal vaccination. Natural killer (NK)-cell and B-cell reconstitution were 
      rapid at 1 month and 3 months, respectively. T-cell recovery was delayed, with a 
      gradual increase in the number of T-cells starting around 6 months 
      post-transplant, and was characterized by a diverse polyclonal T-cell repertoire. 
      Overall, immune reconstitution after haplo-cord transplant is similar to that 
      seen after cord blood transplant, despite infusion of much lower cord blood cell 
      dose.
FAU - Jain, Nitin
AU  - Jain N
AD  - Section of Hematology/Oncology, Department of Medicine, The University of Chicago 
      Medical Center, Chicago, IL, USA.
FAU - Liu, Hongtao
AU  - Liu H
FAU - Artz, Andrew S
AU  - Artz AS
FAU - Anastasi, John
AU  - Anastasi J
FAU - Odenike, Olatoyosi
AU  - Odenike O
FAU - Godley, Lucy A
AU  - Godley LA
FAU - Joseph, Loren
AU  - Joseph L
FAU - Marino, Susana
AU  - Marino S
FAU - Kline, Justin
AU  - Kline J
FAU - Nguyen, Vu
AU  - Nguyen V
FAU - Schouten, Viviane
AU  - Schouten V
FAU - Kunnavakkam, Rangesh
AU  - Kunnavakkam R
FAU - Larson, Richard A
AU  - Larson RA
FAU - Stock, Wendy
AU  - Stock W
FAU - Ulaszek, Jodie
AU  - Ulaszek J
FAU - Savage, Peter A
AU  - Savage PA
FAU - Wickrema, Amittha
AU  - Wickrema A
FAU - van Besien, Koen
AU  - van Besien K
LA  - eng
GR  - P30 CA016672/CA/NCI NIH HHS/United States
GR  - K24 CA 116471/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20130301
PL  - United States
TA  - Leuk Lymphoma
JT  - Leukemia & lymphoma
JID - 9007422
RN  - 0 (Immunoglobulin Isotypes)
RN  - 0 (Pneumococcal Vaccines)
RN  - 0 (Receptors, Antigen, T-Cell)
SB  - IM
MH  - Adult
MH  - Aged
MH  - *Cord Blood Stem Cell Transplantation/adverse effects
MH  - Female
MH  - Graft Survival
MH  - *Haplotypes
MH  - Hematologic Neoplasms/complications/immunology/therapy
MH  - Hematopoiesis/*immunology
MH  - Humans
MH  - Immunoglobulin Isotypes/blood/immunology
MH  - Lymphocyte Count
MH  - Lymphocyte Subsets/immunology/metabolism
MH  - Male
MH  - Middle Aged
MH  - Pneumococcal Vaccines/immunology
MH  - Receptors, Antigen, T-Cell/metabolism
MH  - Transplantation Conditioning
MH  - Transplantation, Homologous
MH  - Virus Diseases/complications/immunology
MH  - Young Adult
EDAT- 2012/10/24 06:00
MHDA- 2013/12/16 06:00
CRDT- 2012/10/24 06:00
PHST- 2012/10/24 06:00 [entrez]
PHST- 2012/10/24 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
AID - 10.3109/10428194.2012.739688 [doi]
PST - ppublish
SO  - Leuk Lymphoma. 2013 Jun;54(6):1242-9. doi: 10.3109/10428194.2012.739688. Epub 
      2013 Mar 1.