PMID- 23089966
OWN - NLM
STAT- MEDLINE
DCOM- 20130604
LR  - 20181202
IS  - 1552-6941 (Electronic)
IS  - 1534-7346 (Linking)
VI  - 11
IP  - 4
DP  - 2012 Dec
TI  - Repair and regeneration of skin injury by transplanting microparticles mixed with 
      Wharton's jelly and MSCs from the human umbilical cord.
PG  - 264-70
LID - 10.1177/1534734612463577 [doi]
AB  - The prognosis for extensive and deep skin injury is not satisfactory because of 
      scar formation and the loss of normal function and skin appendages. Several novel 
      therapies for skin repair and regeneration have emerged. Currently, stem 
      cell-based therapies are attractive candidates in regenerative medicine to treat 
      skin injuries. Human umbilical cord Wharton's jelly-derived mesenchymal stem 
      cells (hUC-MSCs) have become a unique, accessible, and noncontroversial source of 
      regeneration in medicine. The aim of this study was to explore a new strategy for 
      treating skin wounds. A mixture of hUC-MSCs, Wharton's jelly, and skin 
      microparticles were transplanted to 10-mm diameter, full-thickness, middorsal, 
      excisional skin wounds of mice. After 7 days, the tissue sections were sampled 
      for reconstruction analysis and histological examination. After transplantation, 
      there was a remarkable development of newborn skin and its appendages. We could 
      see newly generated layers of epidermis, sebaceous glands, hair follicle, and 
      sweat glands clearly. This innovative strategy could be very promising and may 
      significantly increase the quality of repair and regeneration of skin in 
      injuries.
FAU - Zhang, Yajing
AU  - Zhang Y
AD  - Chinese PLA General Hospital, Beijing, China.
FAU - Hao, Haojie
AU  - Hao H
FAU - Liu, Jiejie
AU  - Liu J
FAU - Fu, Xiaobing
AU  - Fu X
FAU - Han, Weidong
AU  - Han W
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121021
PL  - United States
TA  - Int J Low Extrem Wounds
JT  - The international journal of lower extremity wounds
JID - 101128359
SB  - IM
MH  - Animals
MH  - Disease Models, Animal
MH  - Female
MH  - Humans
MH  - Male
MH  - Mesenchymal Stem Cell Transplantation/*methods
MH  - Mesenchymal Stem Cells/*cytology/metabolism
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Pregnancy
MH  - Regenerative Medicine
MH  - Sensitivity and Specificity
MH  - Skin/*injuries/pathology
MH  - Tissue Engineering
MH  - Umbilical Cord/cytology
MH  - Wharton Jelly/cytology/*transplantation
MH  - Wound Healing/*physiology
EDAT- 2012/10/24 06:00
MHDA- 2013/06/05 06:00
CRDT- 2012/10/24 06:00
PHST- 2012/10/24 06:00 [entrez]
PHST- 2012/10/24 06:00 [pubmed]
PHST- 2013/06/05 06:00 [medline]
AID - 1534734612463577 [pii]
AID - 10.1177/1534734612463577 [doi]
PST - ppublish
SO  - Int J Low Extrem Wounds. 2012 Dec;11(4):264-70. doi: 10.1177/1534734612463577. 
      Epub 2012 Oct 21.