PMID- 23090005
OWN - NLM
STAT- MEDLINE
DCOM- 20140522
LR  - 20211021
IS  - 1861-0293 (Electronic)
IS  - 1340-3443 (Linking)
VI  - 67
IP  - 3
DP  - 2013 Jul
TI  - Fucoidan prevents depression-like behavior in rats exposed to repeated restraint 
      stress.
PG  - 534-44
LID - 10.1007/s11418-012-0712-5 [doi]
AB  - Previous studies have demonstrated that repeated restraint stress in rodents 
      increased depression-like behavior and altered the expression of 
      corticotrophin-releasing factor in the hypothalamus. The current study focused on 
      verifying the impact of fucoidan (FCN) administration on repeated restraint 
      stress-induced behavioral responses using the forced swimming test (FST). 
      Additionally, we examined the effect of FCN on the central noradrenergic system 
      by observing changes in neuronal tyrosine hydroxylase (TH) immunoreactivity and 
      brain-derived neurotrophic factor (BDNF) mRNA expression in the rat brains. Male 
      rats received 10, 20, or 50 mg/kg FCN (i.p.) 30 min before daily exposures to 
      repeated restraint stress (2 h/day) for 14 days. Repeated restraint stress 
      increased immobility in the FST. Daily administration of FCN during the repeated 
      restraint stress period significantly inhibited the stress-induced behavioral 
      deficits in this behavioral test. Administration of FCN also significantly 
      blocked the increase in TH expression in the locus coeruleus and the basolateral 
      nucleus of the amygdala, and the decrease in BDNF mRNA expression in the 
      hippocampus. Taken together, these findings indicate that administration of FCN 
      prior to restraint stress significantly improved helpless behavior in rats, 
      possibly through modulating the central noradrenergic system. Therefore, FCN may 
      be a useful agent for treating complex symptoms of depression disorder.
FAU - Lee, Bombi
AU  - Lee B
AD  - Acupuncture and Meridian Science Research Center, College of Oriental Medicine, 
      Kyung Hee University, 1, Hoegi-dong, Dongdaemun-gu, Seoul, 130-701, Korea. 
      bombi@khu.ac.kr
FAU - Shim, Insop
AU  - Shim I
FAU - Lee, Hyejung
AU  - Lee H
FAU - Hahm, Dae-Hyun
AU  - Hahm DH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121023
PL  - Japan
TA  - J Nat Med
JT  - Journal of natural medicines
JID - 101518405
RN  - 0 (Antidepressive Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Polysaccharides)
RN  - 0 (RNA, Messenger)
RN  - 9072-19-9 (fucoidan)
RN  - EC 1.14.16.2 (Tyrosine 3-Monooxygenase)
RN  - W980KJ009P (Corticosterone)
SB  - IM
MH  - Animals
MH  - Antidepressive Agents/*pharmacology
MH  - Behavior, Animal/drug effects
MH  - Brain/*drug effects/physiopathology
MH  - Brain-Derived Neurotrophic Factor/genetics/metabolism
MH  - Corticosterone/blood
MH  - Depression/etiology/*prevention & control/psychology
MH  - Disease Models, Animal
MH  - Male
MH  - Motor Activity/drug effects
MH  - Polysaccharides/*pharmacology
MH  - RNA, Messenger/metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Restraint, Physical
MH  - Swimming
MH  - Time Factors
MH  - Tyrosine 3-Monooxygenase/metabolism
MH  - Weight Loss/drug effects
EDAT- 2012/10/24 06:00
MHDA- 2014/05/23 06:00
CRDT- 2012/10/24 06:00
PHST- 2012/05/17 00:00 [received]
PHST- 2012/09/29 00:00 [accepted]
PHST- 2012/10/24 06:00 [entrez]
PHST- 2012/10/24 06:00 [pubmed]
PHST- 2014/05/23 06:00 [medline]
AID - 10.1007/s11418-012-0712-5 [doi]
PST - ppublish
SO  - J Nat Med. 2013 Jul;67(3):534-44. doi: 10.1007/s11418-012-0712-5. Epub 2012 Oct 
      23.