PMID- 23090244
OWN - NLM
STAT- MEDLINE
DCOM- 20130930
LR  - 20211021
IS  - 1826-6983 (Electronic)
IS  - 0033-8362 (Linking)
VI  - 118
IP  - 5
DP  - 2013 Aug
TI  - Setup margins and geometric uncertainties in intensity-modulated radiation 
      therapy in treating pituitary adenomas: the experience of Lyon Sud Hospital.
PG  - 863-9
LID - 10.1007/s11547-012-0883-9 [doi]
AB  - PURPOSE: The authors retrospectively evaluated the setup uncertainties in 
      Intensity-Modulated Radiation Therapy (IMRT) for pituitary adenomas and verified 
      the margins used in daily practice (3 mm). MATERIALS AND METHODS: Craniocaudal 
      (CC), anteroposterior (AP) and laterolateral (LL) displacements were measured 
      during the first 3 days of treatment and then weekly by comparing two orthogonal 
      images obtained by an electronic system of portal imaging with Digitally 
      Reconstructed Radiographs (DRRs). Setup Margins (SM) were defined according to 
      the International Commission on Radiation Units (ICRU)-62 formula, the Stroom 
      equation and the van Herk equation. The systematic (Sigma) and random (sigma) errors of 
      the population were calculated as standard deviation (SD) of the population mean 
      and the mean of SDs for every patient, respectively. RESULTS: Twenty patients 
      were treated by IMRT for pituitary adenomas, and a total of 231 measurements were 
      obtained. Sigma and sigma were 0.6 and 1.3 mm, 0.8 and 1 mm, 1.2 and 1.5 mm in the AP, LL 
      and CC direction, respectively. Larger setup margin was 2.4, 2.7 and 4 mm in the 
      AP, LL and CC direction, respectively (van Herk formula). CONCLUSIONS: IMRT is a 
      highly sophisticated treatment technique that requires precise definition and 
      optimisation of local setup errors and, finally, of the irradiated volumes. The 
      role of image-guided RT in these kinds of treatments should be prospectively 
      evaluated.
FAU - De Bari, B
AU  - De Bari B
AD  - Service de Radiotherapie Oncologi, Centre Hospitalier Lyon-Sud, Chemin du 
      Grand-Revoye, 69495, Pierre Benite Cedex, France. bdebari@yahoo.it
FAU - Shakir Shakir, I
AU  - Shakir Shakir I
FAU - Chekrine, T
AU  - Chekrine T
FAU - Lestrade, L
AU  - Lestrade L
FAU - Favrel, V
AU  - Favrel V
LA  - eng
PT  - Journal Article
DEP - 20121022
PL  - Italy
TA  - Radiol Med
JT  - La Radiologia medica
JID - 0177625
SB  - IM
MH  - Adenoma/*radiotherapy
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Pituitary Neoplasms/*radiotherapy
MH  - Radiographic Image Enhancement
MH  - Radiotherapy Planning, Computer-Assisted/*methods
MH  - Radiotherapy, Intensity-Modulated/*methods
MH  - Retrospective Studies
MH  - Tomography, X-Ray Computed
MH  - Treatment Outcome
EDAT- 2012/10/24 06:00
MHDA- 2013/10/01 06:00
CRDT- 2012/10/24 06:00
PHST- 2011/11/29 00:00 [received]
PHST- 2012/03/12 00:00 [accepted]
PHST- 2012/10/24 06:00 [entrez]
PHST- 2012/10/24 06:00 [pubmed]
PHST- 2013/10/01 06:00 [medline]
AID - 10.1007/s11547-012-0883-9 [doi]
PST - ppublish
SO  - Radiol Med. 2013 Aug;118(5):863-9. doi: 10.1007/s11547-012-0883-9. Epub 2012 Oct 
      22.