PMID- 23090289
OWN - NLM
STAT- MEDLINE
DCOM- 20130502
LR  - 20240426
IS  - 1432-0851 (Electronic)
IS  - 0340-7004 (Print)
IS  - 0340-7004 (Linking)
VI  - 62
IP  - 3
DP  - 2013 Mar
TI  - Expression of monocyte chemoattractant protein-1 and CC chemokine receptor 2 in 
      non-small cell lung cancer and its significance.
PG  - 563-70
LID - 10.1007/s00262-012-1361-y [doi]
AB  - Expression of monocyte chemoattractant protein-1 (MCP-1) and CC chemokine 
      receptor 2 (CCR2) and its significance has been demonstrated in some cancer cells 
      in recent clinical studies. However, the role of tumor MCP-1 and CCR2 expression 
      in non-small cell lung cancer (NSCLC) remains unknown. The aim of the present 
      study was to investigate the prognostic significance of MCP-1 and CCR2 expression 
      in NSCLC cells. The relationship between MCP-1 and CCR2 expression in NSCLC 
      cancer cells was examined by immunohistochemical staining of surgical specimens 
      from 134 patients. Sixty-five of these patients had follow-up records. 
      Kaplan-Meier analysis and Cox regression model were used to assess overall 
      survival according to the presence or absence of MCP-1 and CCR2 expression in 
      tumor cells. MCP-1 was detected in cancer cells of 107 NSCLC (79.9 %) and CCR2 
      was detected in cancer cells of 39 NSCLC (29.1 %). MCP-1 expression was 
      correlated with sex, smoking habits, histology, and tumor size. Presence of MCP-1 
      in tumor cells was associated with better overall survival (P = 0.018). By 
      multivariate analysis, MCP-1 expression in cancer cells showed an independent 
      prognostic factor for overall survival (P = 0.002, hazard ratio [HR] = 0.256, 95 
      % confidence interval [CI] = 0.106-0.616). There was no significant relationship 
      between CCR2 expression in tumor cells and clinical and pathological 
      characteristics. Also, no significant positive correlation between MCP-1 and CCR2 
      expression was revealed by Spearman correlation analysis. Our data indicate that 
      MCP-1 is overexpressed in NSCLC cells. Its expression in cancer cells is 
      associated with better survival in NSCLC patients.
FAU - Zhang, Xiao-wei
AU  - Zhang XW
AD  - Department of Respiratory Medicine, Huadong Hospital, Fudan University, 221 
      Yan'an West Road, Shanghai, 200040, China.
FAU - Qin, Xia
AU  - Qin X
FAU - Qin, Crystal Y
AU  - Qin CY
FAU - Yin, Yu-lei
AU  - Yin YL
FAU - Chen, Yan
AU  - Chen Y
FAU - Zhu, Hui-li
AU  - Zhu HL
LA  - eng
PT  - Journal Article
DEP - 20121023
PL  - Germany
TA  - Cancer Immunol Immunother
JT  - Cancer immunology, immunotherapy : CII
JID - 8605732
RN  - 0 (Chemokine CCL2)
RN  - 0 (Receptors, CCR2)
SB  - IM
MH  - Carcinoma, Non-Small-Cell Lung/*metabolism/mortality/pathology
MH  - Chemokine CCL2/*metabolism
MH  - Female
MH  - Humans
MH  - Lung Neoplasms/*metabolism/mortality/pathology
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Receptors, CCR2/*metabolism
MH  - Smoking
PMC - PMC11028706
EDAT- 2012/10/24 06:00
MHDA- 2013/05/03 06:00
PMCR- 2012/10/23
CRDT- 2012/10/24 06:00
PHST- 2012/07/24 00:00 [received]
PHST- 2012/10/03 00:00 [accepted]
PHST- 2012/10/24 06:00 [entrez]
PHST- 2012/10/24 06:00 [pubmed]
PHST- 2013/05/03 06:00 [medline]
PHST- 2012/10/23 00:00 [pmc-release]
AID - 1361 [pii]
AID - 10.1007/s00262-012-1361-y [doi]
PST - ppublish
SO  - Cancer Immunol Immunother. 2013 Mar;62(3):563-70. doi: 10.1007/s00262-012-1361-y. 
      Epub 2012 Oct 23.