PMID- 23090575
OWN - NLM
STAT- MEDLINE
DCOM- 20140326
LR  - 20211021
IS  - 1476-5497 (Electronic)
IS  - 0307-0565 (Print)
IS  - 0307-0565 (Linking)
VI  - 37
IP  - 7
DP  - 2013 Jul
TI  - High energy expenditure masks low physical activity in obesity.
PG  - 1006-11
LID - 10.1038/ijo.2012.172 [doi]
AB  - OBJECTIVE: To investigate energy expenditure in lean and obese individuals, 
      focusing particularly on physical activity and severely obese individuals. 
      DESIGN: Total daily energy expenditure (TDEE) was assessed using doubly labeled 
      water, resting metabolic rate (RMR) by indirect calorimetry, activity energy 
      expenditure (AEE) by difference and time spent in physical activity by 
      multisensor activity monitors. SUBJECTS: In all, 177 lean, Class I and severely 
      obese individuals (age 31-56 years, body mass index 20-64 kg m(-2)) were 
      analyzed. RESULTS: All components of energy expenditure were elevated in obese 
      individuals. For example, TDEE was 2404+/-95 kcal per day in lean and 3244+/-48 kcal 
      per day in Class III obese individuals. After appropriate adjustment, RMR was 
      similar in all groups. Analysis of AEE by body weight and obesity class indicated 
      a lower AEE in obese individuals. Confirming lower physical activity, obese 
      individuals spent less time engaged in moderate-to-vigorous physical activity 
      (2.7+/-1.3, 1.8+/-0.6, 2.0+/-1.4 and 1.2+/-1.0 h per day in lean, Class I, Class II and 
      Class III individuals) and more time in sedentary behaviors. CONCLUSIONS: There 
      was no indication of metabolic efficiency in even the severely obese, as adjusted 
      RMR was similar across all groups. The higher AEE observed in the obese is 
      consistent with a higher cost of activities due to higher body weight. However, 
      the magnitude of the higher AEE (20-25% higher in obese individuals) is lower 
      than expected (weight approximately 100% higher in Class III individuals). 
      Confirming a lower volume of physical activity in the obese, the total time spent 
      in moderate-to-vigorous physical activity and average daily metabolic equivalent 
      of task level were lower with increasing obesity. These findings demonstrate that 
      high body weight in obese individuals leads to a high TDEE and AEE, which masks 
      the fact that they are less physically active, which can be influenced by 
      duration or intensity of activity, than in lean individuals.
FAU - DeLany, J P
AU  - DeLany JP
AD  - Division of Endocrinology and Metabolism, Department of Medicine, School of 
      Medicine, Pittsburgh, PA 15213, USA. jpd21@pitt.edu
FAU - Kelley, D E
AU  - Kelley DE
FAU - Hames, K C
AU  - Hames KC
FAU - Jakicic, J M
AU  - Jakicic JM
FAU - Goodpaster, B H
AU  - Goodpaster BH
LA  - eng
GR  - P30 AG024827/AG/NIA NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121023
PL  - England
TA  - Int J Obes (Lond)
JT  - International journal of obesity (2005)
JID - 101256108
SB  - IM
MH  - Adult
MH  - Calorimetry, Indirect
MH  - Cross-Sectional Studies
MH  - *Energy Metabolism
MH  - *Exercise
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Obesity, Morbid/epidemiology/*metabolism/physiopathology
MH  - *Physical Exertion
MH  - Thinness/epidemiology/*metabolism/physiopathology
MH  - Time Factors
MH  - United States/epidemiology
PMC - PMC4879834
MID - NIHMS539518
COIS- Conflict of interest JMJ conflicts of interest: Scientific Advisory Board for 
      Alere Wellbeing, Honorarium for scientific presentation from JennyCraig/Nestle 
      Nutrition Institute, Research funding provided to Pitt by BodyMedia, Inc. The 
      other authors report no conflict of interest.
EDAT- 2012/10/24 06:00
MHDA- 2014/03/29 06:00
PMCR- 2016/05/25
CRDT- 2012/10/24 06:00
PHST- 2012/06/19 00:00 [received]
PHST- 2012/09/06 00:00 [revised]
PHST- 2012/09/09 00:00 [accepted]
PHST- 2012/10/24 06:00 [entrez]
PHST- 2012/10/24 06:00 [pubmed]
PHST- 2014/03/29 06:00 [medline]
PHST- 2016/05/25 00:00 [pmc-release]
AID - ijo2012172 [pii]
AID - 10.1038/ijo.2012.172 [doi]
PST - ppublish
SO  - Int J Obes (Lond). 2013 Jul;37(7):1006-11. doi: 10.1038/ijo.2012.172. Epub 2012 
      Oct 23.