PMID- 23091545
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121024
LR  - 20211021
IS  - 2092-9900 (Electronic)
IS  - 1738-6756 (Print)
IS  - 1738-6756 (Linking)
VI  - 15
IP  - 3
DP  - 2012 Sep
TI  - Correlation of conventional and conformal plan parameters for predicting 
      radiation pneumonitis in patients treated with breast cancer.
PG  - 320-8
LID - 10.4048/jbc.2012.15.3.320 [doi]
AB  - PURPOSE: The purpose of this study is to evaluate the correlation between the 
      conventional plan parameters and dosimetric parameters obtained from conformal 
      radiotherapy (RT) planning, and between these parameters and radiation 
      pneumontitis (RP) incidence. METHODS: Clinical and dosimetric data of 122 
      patients that were treated with mastectomy and adjuvant 3D conformal RT (39% 
      received 2-field RT [2-FRT], and in addition, 61% received 4-field RT [4-FRT]) 
      were retrospectively analyzed. Central lung depth (CLD), maximum lung depth 
      (MLD), and lung length were measured by the conventional plan. Lung dose-volume 
      histograms (DVH) were created with conformal planning, and the lung volumes 
      receiving 5 to 50 Gy (V(5Gy) to V(50Gy)) were calculated. Minimum (D(min)), 
      maximum (D(max)), and mean doses (D(mean)) for the ipsilateral lung and bilateral 
      lungs were measured by DVH. Correlations between 3D dosimetric data and 2D 
      radiographic parameters were analyzed. RESULTS: The conventional plan parameters 
      did not significantly differ between 2-FRT and 4-FRT. The conformal plan D(min), 
      D(max), and D(mean) values were higher in 4-FRT versus 2-FRT. CLD and MLD were 
      correlated with DVH parameter V(5Gy) to V(45Gy) values for ipsilateral, as well 
      as bilateral lungs for 2-FRT. MLD and ipsilateral D(mean) via 2-FRT planning had 
      the strongest positive correlation (r=0.76, p<0.01). Moderate correlations 
      existed between CLD and ipsilateral and bilateral lung V(5Gy-45Gy), and between 
      MLD and bilateral lung V(5Gy-45Gy) values in 2-FRT. Only four patients developed 
      symptomatic RP, 4 with 4-FRT and one with 2-FRT. CONCLUSION: The conformal plan 
      parameters were strongly correlated with dose-volume parameters for breast 2-FRT. 
      With only 4 cases of Grade 3 RP observed, our study is limited in its ability to 
      provide definitive guidance, however assuming that CLD is an indicator for RP, 
      V(20Gy) could be used as a predictor for RP and for 2-FRT. A well-defined 
      parameters are still required to predict RP in 4-FRT.
FAU - Onal, Cem
AU  - Onal C
AD  - Department of Radiation Oncology, Baskent University Faculty of Medicine, Adana 
      Research and Treatment Centre, Adana, Turkey.
FAU - Oymak, Ezgi
AU  - Oymak E
FAU - Kotek, Ayse
AU  - Kotek A
FAU - Efe, Esma
AU  - Efe E
FAU - Arslan, Gungor
AU  - Arslan G
LA  - eng
PT  - Journal Article
DEP - 20120928
PL  - Korea (South)
TA  - J Breast Cancer
JT  - Journal of breast cancer
JID - 101314183
PMC - PMC3468786
OTO - NOTNLM
OT  - Adjuvant radiotherapy
OT  - Breast neoplasms
OT  - Conformal radiotherapy
OT  - Radiation pneumonitis
OT  - Radiotherapy
COIS- We have no personal or financial conflict of interest and have not entered into 
      any agreement that could interfere with our access to the data on the research, 
      or upon our ability to analyze the data independently, to prepare manuscripts, 
      and to publish them.
EDAT- 2012/10/24 06:00
MHDA- 2012/10/24 06:01
PMCR- 2012/09/01
CRDT- 2012/10/24 06:00
PHST- 2012/02/16 00:00 [received]
PHST- 2012/05/02 00:00 [accepted]
PHST- 2012/10/24 06:00 [entrez]
PHST- 2012/10/24 06:00 [pubmed]
PHST- 2012/10/24 06:01 [medline]
PHST- 2012/09/01 00:00 [pmc-release]
AID - 10.4048/jbc.2012.15.3.320 [doi]
PST - ppublish
SO  - J Breast Cancer. 2012 Sep;15(3):320-8. doi: 10.4048/jbc.2012.15.3.320. Epub 2012 
      Sep 28.