PMID- 23091554
OWN - NLM
STAT- MEDLINE
DCOM- 20130516
LR  - 20221207
IS  - 1740-2530 (Electronic)
IS  - 1740-2522 (Print)
IS  - 1740-2522 (Linking)
VI  - 2012
DP  - 2012
TI  - The genetic polymorphisms of HLA are strongly correlated with the disease 
      severity after Hantaan virus infection in the Chinese Han population.
PG  - 308237
LID - 10.1155/2012/308237 [doi]
LID - 308237
AB  - The polymorphism of human leukocyte antigen (HLA), which is a genetic factor that 
      influences the progression of hemorrhagic fever with renal syndrome (HFRS) after 
      Hantaan virus (HTNV) infection, was incompletely understood. In this case-control 
      study, 76 HFRS patients and 370 healthy controls of the Chinese Han population 
      were typed for the HLA-A, -B, and -DRB1 loci. The general variation at the 
      HLA-DRB1 locus was associated with the onset of HFRS (P < 0.05). The increasing 
      frequencies of HLA-DRB1 *09 and HLA-B*46-DRB1*09 in HFRS patients were observed as 
      reproducing a previous study. Moreover, the HLA-B*51-DRB1*09 was susceptible to 
      HFRS (P = 0.037; OR = 3.62; 95% CI: 1.00-13.18). The increasing frequencies of 
      HLA-B*46, HLA-B*46-DRB1*09, and HLA-B*51-DRB1*09 were observed almost in 
      severe/critical HFRS patients. The mean level of maximum serum creatinine was 
      higher in HLA-B *46-DRB1*09 (P = 0.011), HLA-B*51-DRB1*09 (P = 0.041), or HLA-B*46 
      (P = 0.011) positive patients than that in the negative patients. These findings 
      suggest that the allele HLA-B*46 and haplotypes HLA-B*46-DRB1*09 and 
      HLA-B*51-DRB1*09 in patients could contribute to a more severe degree of HFRS and 
      more serious kidney injury, which improve our understanding of the HLA 
      polymorphism for a different outcome of HTNV infection.
FAU - Ma, Ying
AU  - Ma Y
AD  - Department of Immunology, The Fourth Military Medical University, 169 Changle 
      West Road, Xi'an 710032, China.
FAU - Yuan, Bin
AU  - Yuan B
FAU - Yi, Jing
AU  - Yi J
FAU - Zhuang, Ran
AU  - Zhuang R
FAU - Wang, Jiuping
AU  - Wang J
FAU - Zhang, Yun
AU  - Zhang Y
FAU - Xu, Zhuwei
AU  - Xu Z
FAU - Zhang, Yusi
AU  - Zhang Y
FAU - Liu, Bei
AU  - Liu B
FAU - Wei, Chao
AU  - Wei C
FAU - Zhang, Chunmei
AU  - Zhang C
FAU - Yang, Angang
AU  - Yang A
FAU - Jin, Boquan
AU  - Jin B
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121008
PL  - Egypt
TA  - Clin Dev Immunol
JT  - Clinical & developmental immunology
JID - 101183692
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Alleles
MH  - Asian People/genetics
MH  - Case-Control Studies
MH  - Female
MH  - Gene Frequency/immunology
MH  - Genetic Predisposition to Disease
MH  - HLA-A Antigens/*genetics/immunology
MH  - HLA-B Antigens/*genetics/immunology
MH  - HLA-DRB1 Chains/*genetics/immunology
MH  - Hantaan virus/*immunology
MH  - Haplotypes
MH  - Hemorrhagic Fever with Renal Syndrome/*genetics/immunology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Genetic/*genetics/immunology
MH  - Population Groups/genetics
PMC - PMC3472611
EDAT- 2012/10/24 06:00
MHDA- 2013/05/17 06:00
PMCR- 2012/10/08
CRDT- 2012/10/24 06:00
PHST- 2012/07/26 00:00 [received]
PHST- 2012/09/05 00:00 [accepted]
PHST- 2012/10/24 06:00 [entrez]
PHST- 2012/10/24 06:00 [pubmed]
PHST- 2013/05/17 06:00 [medline]
PHST- 2012/10/08 00:00 [pmc-release]
AID - 10.1155/2012/308237 [doi]
PST - ppublish
SO  - Clin Dev Immunol. 2012;2012:308237. doi: 10.1155/2012/308237. Epub 2012 Oct 8.