PMID- 23092130
OWN - NLM
STAT- MEDLINE
DCOM- 20130506
LR  - 20220318
IS  - 1875-533X (Electronic)
IS  - 0929-8673 (Linking)
VI  - 20
IP  - 1
DP  - 2013
TI  - Thermosensitive polymeric hydrogels as drug delivery systems.
PG  - 79-94
AB  - Thermosensitive hydrogels are very important biomaterials used in drug delivery 
      systems (DDSs), which gained increasing attention of researchers. Thermosensitive 
      hydrogels have great potential in various applications, such as drug delivery, 
      cell encapsulation, tissue engineering, and etc. Especially, injectable 
      thermosensitive hydrogels with lower sol-gel transition temperature around 
      physiological temperature have been extensively studied. By in vivo injection, 
      the hydrogels formed non-flowing gel at body temperature. Upon incorporation of 
      pharmaceutical agents, the hydrogel systems could act as sustained drug release 
      depot in situ. Injectable thermosensitive hydrogel systems have a number of 
      advantages, including simplicity of drug formulation, protective environment for 
      drugs, prolonged and localized drug delivery, and ease of application. The 
      objective of this review is to summarize fundamentals, applications, and recent 
      advances of injectable thermosensitive hydrogel as DDSs, including chitosan and 
      related derivatives, poly(N-isopropylacrylamide)-based (PNIPAAM) copolymers, 
      poly(ethylene oxide)/poly(propylene oxide) (PEO/PPO) copolymers and its 
      derivatives, and poly(ethylene glycol)/ biodegradable polyester copolymers.
FAU - Gong, C
AU  - Gong C
AD  - State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West 
      China Medical School, Sichuan University, Chengdu, 610041, China.
FAU - Qi, T
AU  - Qi T
FAU - Wei, X
AU  - Wei X
FAU - Qu, Y
AU  - Qu Y
FAU - Wu, Q
AU  - Wu Q
FAU - Luo, F
AU  - Luo F
FAU - Qian, Z
AU  - Qian Z
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United Arab Emirates
TA  - Curr Med Chem
JT  - Current medicinal chemistry
JID - 9440157
RN  - 0 (Delayed-Action Preparations)
RN  - 0 (Hydrogels)
RN  - 0 (Pharmaceutical Preparations)
RN  - 0 (Polymers)
SB  - IM
MH  - Animals
MH  - Delayed-Action Preparations/*chemistry
MH  - Drug Delivery Systems/*methods
MH  - Humans
MH  - Hydrogels
MH  - Injections
MH  - Pharmaceutical Preparations/*administration & dosage
MH  - Polymers/*chemistry
MH  - Temperature
EDAT- 2012/10/25 06:00
MHDA- 2013/05/07 06:00
CRDT- 2012/10/25 06:00
PHST- 2012/04/26 00:00 [received]
PHST- 2012/10/16 00:00 [revised]
PHST- 2012/10/16 00:00 [accepted]
PHST- 2012/10/25 06:00 [entrez]
PHST- 2012/10/25 06:00 [pubmed]
PHST- 2013/05/07 06:00 [medline]
AID - CMC-EPUB-20121017-4 [pii]
PST - ppublish
SO  - Curr Med Chem. 2013;20(1):79-94.