PMID- 23093487
OWN - NLM
STAT- MEDLINE
DCOM- 20130307
LR  - 20211021
IS  - 1945-7197 (Electronic)
IS  - 0021-972X (Print)
IS  - 0021-972X (Linking)
VI  - 98
IP  - 1
DP  - 2013 Jan
TI  - Association of type-O blood with neuroendocrine tumors in multiple endocrine 
      neoplasia type 1.
PG  - E109-14
LID - 10.1210/jc.2012-2781 [doi]
AB  - CONTEXT: The ABO blood type system describes the expression of human blood group 
      antigens found on both erythrocytes and normal tissue throughout the body. We 
      recently reported an association between O blood type and the manifestation of 
      pancreatic neuroendocrine tumors in a cohort of patients with Von Hippel-Lindau 
      syndrome. OBJECTIVE: The aim of the study was to determine whether there is an 
      association of ABO blood type with the development of neuroendocrine tumors in 
      patients with multiple endocrine neoplasia, type 1 (MEN-1). DESIGN: A 
      retrospective analysis of 105 patients with MEN-1 was performed. Demographic, 
      clinical, and biochemical data were analyzed by ABO blood type. Fisher's exact 
      test was used to determine association between ABO blood type and manifestation 
      of neuroendocrine tumor. RESULTS: Demographic and clinical characteristics were 
      similar amongst blood type cohorts. We found an association between O blood type 
      and the manifestation of a primary neuroendocrine tumor of the gastrointestinal 
      tract, lung, pancreas, and thymus in patients with MEN-1 (P = 0.01). Sixteen of 
      17 (94%) metastatic tumors had type-O blood, compared to 32 of 43 (74%) with a 
      benign tumor who had non-O blood type. CONCLUSIONS: Our findings suggest an 
      association between O blood type and the manifestation of a primary 
      neuroendocrine tumor in patients with MEN-1. Prospective clinical studies are 
      warranted to see whether patient blood type status may be a useful addition to 
      current screening and surveillance practices.
FAU - Weisbrod, Allison B
AU  - Weisbrod AB
AD  - Endocrine Oncology Branch, National Cancer Institute, National Institutes of 
      Health, Bethesda, Maryland 20892, USA. abweisbrod@gmail.com
FAU - Nilubol, Naris
AU  - Nilubol N
FAU - Weinstein, Lee S
AU  - Weinstein LS
FAU - Simonds, William F
AU  - Simonds WF
FAU - Libutti, Steven K
AU  - Libutti SK
FAU - Jensen, Robert T
AU  - Jensen RT
FAU - Marx, Stephen J
AU  - Marx SJ
FAU - Kebebew, Electron
AU  - Kebebew E
LA  - eng
GR  - Intramural NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Intramural
DEP - 20121023
PL  - United States
TA  - J Clin Endocrinol Metab
JT  - The Journal of clinical endocrinology and metabolism
JID - 0375362
RN  - 0 (ABO Blood-Group System)
SB  - IM
MH  - ABO Blood-Group System/genetics/*physiology
MH  - Adult
MH  - Aged
MH  - Cohort Studies
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Multiple Endocrine Neoplasia Type 1/*blood/complications/mortality/pathology
MH  - Neuroendocrine Tumors/*blood/complications/mortality/pathology
MH  - Pancreatic Neoplasms/*blood/complications/mortality/pathology
MH  - Retrospective Studies
MH  - Survival Analysis
MH  - Young Adult
PMC - PMC3537107
EDAT- 2012/10/25 06:00
MHDA- 2013/03/08 06:00
PMCR- 2014/01/01
CRDT- 2012/10/25 06:00
PHST- 2012/10/25 06:00 [entrez]
PHST- 2012/10/25 06:00 [pubmed]
PHST- 2013/03/08 06:00 [medline]
PHST- 2014/01/01 00:00 [pmc-release]
AID - jc.2012-2781 [pii]
AID - 12-2781 [pii]
AID - 10.1210/jc.2012-2781 [doi]
PST - ppublish
SO  - J Clin Endocrinol Metab. 2013 Jan;98(1):E109-14. doi: 10.1210/jc.2012-2781. Epub 
      2012 Oct 23.