PMID- 23093701
OWN - NLM
STAT- MEDLINE
DCOM- 20130305
LR  - 20161018
IS  - 1479-683X (Electronic)
IS  - 0804-4643 (Linking)
VI  - 168
IP  - 2
DP  - 2013 Feb
TI  - Proteomic biomarkers of type 2 diabetes mellitus risk in women with polycystic 
      ovary syndrome.
PG  - R33-43
LID - 10.1530/EJE-12-0718 [doi]
AB  - Women with polycystic ovary syndrome (PCOS) are at increased risk of developing 
      insulin resistance and type 2 diabetes mellitus (T2DM). In this study, we 
      attempted to list the proteomic biomarkers of PCOS and T2DM that have been 
      published in the literature so far. We identified eight common biomarkers that 
      were differentially expressed in both women with PCOS and T2DM when compared with 
      healthy controls. These include pyruvate kinase M1/M2, apolipoprotein A-I, 
      albumin, peroxiredoxin 2, annexin A2, alpha-1-B-glycoprotein, flotillin-1 and 
      haptoglobin. These biomarkers could help improve our understanding of the links 
      between PCOS and T2DM and could be potentially used to identify subgroups of 
      women with PCOS at increased risk of T2DM. More studies are required to further 
      evaluate the role these biomarkers play in women with PCOS and T2DM.
FAU - Galazis, Nicolas
AU  - Galazis N
AD  - Division of Human Development, School of Clinical Sciences, Nottingham University 
      Hospitals, University of Nottingham D Floor, East Block, Queens Medical Centre 
      Campus, Nottingham NG7 2UH, UK. ngalazis@gmail.com
FAU - Afxentiou, Thalia
AU  - Afxentiou T
FAU - Xenophontos, Mikalena
AU  - Xenophontos M
FAU - Diamanti-Kandarakis, Evanthia
AU  - Diamanti-Kandarakis E
FAU - Atiomo, William
AU  - Atiomo W
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20130201
PL  - England
TA  - Eur J Endocrinol
JT  - European journal of endocrinology
JID - 9423848
RN  - 0 (Albumins)
RN  - 0 (Annexin A2)
RN  - 0 (Apolipoproteins A)
RN  - 0 (Biomarkers)
RN  - 0 (Haptoglobins)
RN  - 0 (Membrane Proteins)
RN  - 0 (flotillins)
RN  - EC 1.11.1.15 (Peroxiredoxins)
RN  - EC 2.7.1.40 (Pyruvate Kinase)
SB  - IM
MH  - Adult
MH  - Albumins/metabolism
MH  - Annexin A2/metabolism
MH  - Apolipoproteins A/metabolism
MH  - Biomarkers/*metabolism
MH  - Diabetes Mellitus, Type 2/*metabolism
MH  - Female
MH  - Haptoglobins/metabolism
MH  - Humans
MH  - Membrane Proteins/metabolism
MH  - Peroxiredoxins/metabolism
MH  - Polycystic Ovary Syndrome/*metabolism
MH  - Proteomics
MH  - Pyruvate Kinase/metabolism
MH  - Risk Factors
EDAT- 2012/10/25 06:00
MHDA- 2013/03/06 06:00
CRDT- 2012/10/25 06:00
PHST- 2012/10/25 06:00 [entrez]
PHST- 2012/10/25 06:00 [pubmed]
PHST- 2013/03/06 06:00 [medline]
AID - EJE-12-0718 [pii]
AID - 10.1530/EJE-12-0718 [doi]
PST - epublish
SO  - Eur J Endocrinol. 2013 Feb 1;168(2):R33-43. doi: 10.1530/EJE-12-0718. Print 2013 
      Feb.