PMID- 23093796
OWN - NLM
STAT- MEDLINE
DCOM- 20130502
LR  - 20121127
IS  - 1440-1592 (Electronic)
IS  - 1323-8930 (Linking)
VI  - 61
IP  - 4
DP  - 2012 Dec
TI  - Wheat-dependent exercise-induced anaphylaxis sensitized with hydrolyzed wheat 
      protein in soap.
PG  - 529-37
LID - 10.2332/allergolint.12-RAI-0494 [doi]
AB  - Wheat-dependent exercise-induced anaphylaxis (WDEIA) is a specific form of wheat 
      allergy typically induced by exercise after ingestion of wheat products. Wheat 
      omega-5 gliadin is a major allergen associated with conventional WDEIA, and detection 
      of serum immunoglobulin E (IgE) specific to recombinant omega-5 gliadin is a reliable 
      method for its diagnosis. Recently, an increased incidence of a new subtype of 
      WDEIA, which is likely to be sensitized via a percutaneous and/or 
      rhinoconjunctival route to hydrolyzed wheat protein (HWP), has been observed. All 
      of the patients with this new subtype had used the same brand of soap, which 
      contained HWP. Approximately half of these patients developed contact allergy 
      several months later and subsequently developed WDEIA. In each of these patients, 
      contact allergy with soap exposure preceded food ingestion-induced reactions. 
      Other patients directly developed generalized symptoms upon ingestion of wheat 
      products. The predominant observed symptom of the new WDEIA subtype was 
      angioedema of the eyelids; a number of patients developed anaphylaxis. This new 
      subtype of WDEIA has little serum omega-5 gliadin-specific serum IgE.
FAU - Chinuki, Yuko
AU  - Chinuki Y
AD  - Department of Dermatology, Shimane University Faculty of Medicine, Japan. 
      ychinuki@med.shimane-u.ac.jp
FAU - Morita, Eishin
AU  - Morita E
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Review
DEP - 20121025
PL  - England
TA  - Allergol Int
JT  - Allergology international : official journal of the Japanese Society of 
      Allergology
JID - 9616296
RN  - 0 (Allergens)
RN  - 0 (Antigens, Plant)
RN  - 0 (ENPP3 protein, human)
RN  - 0 (Soaps)
RN  - 0 (omega-5 gliadin, wheat)
RN  - 9007-90-3 (Gliadin)
RN  - EC 3.1.4.- (Phosphoric Diester Hydrolases)
RN  - EC 3.6.1.- (Pyrophosphatases)
SB  - IM
MH  - Allergens/*immunology/metabolism
MH  - Anaphylaxis/diagnosis/*etiology/prevention & control
MH  - Antigens, Plant/*immunology/metabolism
MH  - Basophils/immunology/metabolism
MH  - *Exercise
MH  - Female
MH  - Gliadin/*immunology/metabolism
MH  - Humans
MH  - Middle Aged
MH  - Phosphoric Diester Hydrolases/metabolism
MH  - Pyrophosphatases/metabolism
MH  - Soaps/adverse effects/*chemistry
MH  - Wheat Hypersensitivity/diagnosis/*etiology/prevention & control
EDAT- 2012/10/25 06:00
MHDA- 2013/05/03 06:00
CRDT- 2012/10/25 06:00
PHST- 2012/08/19 00:00 [received]
PHST- 2012/10/25 06:00 [entrez]
PHST- 2012/10/25 06:00 [pubmed]
PHST- 2013/05/03 06:00 [medline]
AID - S1323-8930(15)30253-7 [pii]
AID - 10.2332/allergolint.12-RAI-0494 [doi]
PST - ppublish
SO  - Allergol Int. 2012 Dec;61(4):529-37. doi: 10.2332/allergolint.12-RAI-0494. Epub 
      2012 Oct 25.