PMID- 23094149
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121025
LR  - 20230502
IS  - 2090-1844 (Electronic)
IS  - 2090-1836 (Print)
IS  - 2090-1844 (Linking)
VI  - 2012
DP  - 2012
TI  - The immune response and its therapeutic modulation in bronchiectasis.
PG  - 280528
LID - 10.1155/2012/280528 [doi]
LID - 280528
AB  - Bronchiectasis (BC) is a chronic pulmonary disease with tremendous morbidity and 
      significant mortality. As pathogen infection has been advocated as a triggering 
      insult in the development of BC, a central role for the immune response in this 
      process seems obvious. Inflammatory cells are present in both the airways as well 
      as the lung parenchyma, and multiple mediators of immune cells including 
      proteases and cytokines or their humoral products are increased locally or in the 
      periphery. Interestingly, a defect in the immune system or suppression of immune 
      response during conditions such as immunodeficiency may well predispose one to 
      the devastating effects of BC. Thus, the outcome of an active immune response as 
      detrimental or protective in the pathogenesis of BC may be dependent on the state 
      of the patient's immunity, the severity of infection, and the magnitude of immune 
      response. Here we reassess the function of the innate and acquired immunity in 
      BC, the major sites of immune response, and the nature of the bioactive 
      mediators. Furthermore, the potential link(s) between an ongoing immune response 
      and structural alterations accompanying the disease and the success of therapies 
      that can modulate the nature and extent of immune response in BC are elaborated 
      upon.
FAU - Daheshia, Massoud
AU  - Daheshia M
AD  - Department of Pulmonary Medicine, Naval Medical Center San Diego, San Diego, CA 
      92134, USA.
FAU - Prahl, James D
AU  - Prahl JD
FAU - Carmichael, Jacob J
AU  - Carmichael JJ
FAU - Parrish, John S
AU  - Parrish JS
FAU - Seda, Gilbert
AU  - Seda G
LA  - eng
PT  - Journal Article
DEP - 20121010
PL  - Egypt
TA  - Pulm Med
JT  - Pulmonary medicine
JID - 101558762
PMC - PMC3474275
EDAT- 2012/10/25 06:00
MHDA- 2012/10/25 06:01
PMCR- 2012/10/10
CRDT- 2012/10/25 06:00
PHST- 2012/06/20 00:00 [received]
PHST- 2012/09/04 00:00 [accepted]
PHST- 2012/10/25 06:00 [entrez]
PHST- 2012/10/25 06:00 [pubmed]
PHST- 2012/10/25 06:01 [medline]
PHST- 2012/10/10 00:00 [pmc-release]
AID - 10.1155/2012/280528 [doi]
PST - ppublish
SO  - Pulm Med. 2012;2012:280528. doi: 10.1155/2012/280528. Epub 2012 Oct 10.