PMID- 23094873
OWN - NLM
STAT- MEDLINE
DCOM- 20130110
LR  - 20191210
IS  - 1471-4159 (Electronic)
IS  - 0022-3042 (Linking)
VI  - 123
IP  - 5
DP  - 2012 Dec
TI  - Elevated expression of brain-derived neurotrophic factor facilitates visual 
      imprinting in chicks.
PG  - 800-10
LID - 10.1111/jnc.12039 [doi]
AB  - With the aim of elucidating the neural mechanisms of early learning, we studied 
      the role of brain-derived neurotrophic factor (BDNF) in visual imprinting in 
      birds. The telencephalic neural circuit connecting the visual Wulst and 
      intermediate medial mesopallium is critical for imprinting, and the core region 
      of the hyperpallium densocellulare (HDCo), situated at the center of this 
      circuit, has a key role in regulating the activity of the circuit. We found that 
      the number of BDNF mRNA-positive cells in the HDCo was elevated during the 
      critical period, particularly at its onset, on the day of hatching (P0). After 
      imprinting training on P1, BDNF mRNA-positive cells in the HDCo increased in 
      number, and tyrosine phosphorylation of TrkB was observed. BDNF infusion into the 
      HDCo at P1 induced imprinting, even with a weak training protocol that does not 
      normally induce imprinting. In contrast, K252a, an antagonist of Trk, inhibited 
      imprinting. Injection of BDNF at P7, after the critical period, did not elicit 
      imprinting. These results suggest that BDNF promotes the induction of imprinting 
      through TrkB exclusively during the critical period.
CI  - (c) 2012 The Authors Journal of Neurochemistry (c) 2012 International Society for 
      Neurochemistry.
FAU - Suzuki, Keiko
AU  - Suzuki K
AD  - Division of Biology, College of Liberal Arts and Sciences, Kitasato University, 
      Sagamihara, Kanagawa, Japan.
FAU - Maekawa, Fumihiko
AU  - Maekawa F
FAU - Suzuki, Shingo
AU  - Suzuki S
FAU - Nakamori, Tomoharu
AU  - Nakamori T
FAU - Sugiyama, Hayato
AU  - Sugiyama H
FAU - Kanamatsu, Tomoyuki
AU  - Kanamatsu T
FAU - Tanaka, Kohichi
AU  - Tanaka K
FAU - Ohki-Hamazaki, Hiroko
AU  - Ohki-Hamazaki H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121025
PL  - England
TA  - J Neurochem
JT  - Journal of neurochemistry
JID - 2985190R
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (RNA, Messenger)
RN  - EC 2.7.10.1 (Receptor, trkB)
SB  - IM
MH  - Animals
MH  - Blotting, Western
MH  - Brain-Derived Neurotrophic Factor/*biosynthesis
MH  - Chickens
MH  - *Critical Period, Psychological
MH  - HEK293 Cells
MH  - Humans
MH  - Immunohistochemistry
MH  - Imprinting, Psychological/*physiology
MH  - In Situ Hybridization
MH  - RNA, Messenger/analysis
MH  - Receptor, trkB/*metabolism
MH  - Transfection
MH  - Visual Pathways/*metabolism
EDAT- 2012/10/26 06:00
MHDA- 2013/01/11 06:00
CRDT- 2012/10/26 06:00
PHST- 2012/03/13 00:00 [received]
PHST- 2012/09/13 00:00 [revised]
PHST- 2012/09/28 00:00 [accepted]
PHST- 2012/10/26 06:00 [entrez]
PHST- 2012/10/26 06:00 [pubmed]
PHST- 2013/01/11 06:00 [medline]
AID - 10.1111/jnc.12039 [doi]
PST - ppublish
SO  - J Neurochem. 2012 Dec;123(5):800-10. doi: 10.1111/jnc.12039. Epub 2012 Oct 25.