PMID- 23095911
OWN - NLM
STAT- MEDLINE
DCOM- 20130409
LR  - 20121025
IS  - 1473-6322 (Electronic)
IS  - 1473-6322 (Linking)
VI  - 12
IP  - 6
DP  - 2012 Dec
TI  - Immunotherapy for allergic fungal sinusitis.
PG  - 629-34
LID - 10.1097/ACI.0b013e328357a233 [doi]
AB  - PURPOSE OF REVIEW: Allergic fungal sinusitis (AFS) results from an immunoglobulin 
      E (IgE)-mediated, eosinophil-predominant hypersensitivity reaction to 
      extramucosal fungi within the paranasal sinuses. Although the pathogenesis of 
      this noninvasive process is still not fully understood, there is new information. 
      Recently, the use of allergen immunotherapy with fungal antigens as an adjunct in 
      treatment of AFS has been evaluated. In this review, we summarize the experience 
      in the published literature on the topic. RECENT FINDINGS: There is evidence to 
      suggest that allergen immunotherapy to fungal allergens may be effective in the 
      treatment of symptoms of AFS and may decrease the rate of postoperative 
      exacerbations and further operations. There is no evidence that this therapy 
      induces immune complex disease. These studies pave the way for controlled trials 
      of immunotherapy in patients with AFS. SUMMARY: Allergen immunotherapy to fungi 
      shows promise as a treatment to decrease the recurrence of AFS and should be 
      considered a part of the treatment regimen. However, because the number of 
      patients treated has been small and one study suggested that fungal immunotherapy 
      administered before removal of fungal contents from the sinuses could worsen 
      sinusitis, controlled studies are essential to moving forward.
FAU - Hall, Ashley G
AU  - Hall AG
AD  - Departments of Medicine and Pediatrics, Division of Clinical Immunology and 
      Allergy, University of Mississippi Medical Center, Jackson, Mississippi, USA.
FAU - deShazo, Richard D
AU  - deShazo RD
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Curr Opin Allergy Clin Immunol
JT  - Current opinion in allergy and clinical immunology
JID - 100936359
RN  - 0 (Antigens, Fungal)
SB  - IM
MH  - Animals
MH  - Antigens, Fungal/*therapeutic use
MH  - Desensitization, Immunologic/*methods
MH  - Eosinophils/immunology/microbiology
MH  - Humans
MH  - Mycoses/immunology/*microbiology/*therapy
MH  - Sinusitis/immunology/*microbiology/*therapy
EDAT- 2012/10/26 06:00
MHDA- 2013/04/10 06:00
CRDT- 2012/10/26 06:00
PHST- 2012/10/26 06:00 [entrez]
PHST- 2012/10/26 06:00 [pubmed]
PHST- 2013/04/10 06:00 [medline]
AID - 00130832-201212000-00010 [pii]
AID - 10.1097/ACI.0b013e328357a233 [doi]
PST - ppublish
SO  - Curr Opin Allergy Clin Immunol. 2012 Dec;12(6):629-34. doi: 
      10.1097/ACI.0b013e328357a233.