PMID- 23095916
OWN - NLM
STAT- MEDLINE
DCOM- 20140108
LR  - 20191210
IS  - 1364-5528 (Electronic)
IS  - 0003-2654 (Linking)
VI  - 138
IP  - 1
DP  - 2013 Jan 7
TI  - 2p or not 2p: tuppence-based SERS for the detection of illicit materials.
PG  - 118-22
LID - 10.1039/c2an35974j [doi]
AB  - Deposition of silver onto British 2p coins has been demonstrated as an efficient 
      and cost effective approach to producing substrates capable of promoting surface 
      enhanced Raman scattering (SERS). Silver application to the copper coins is 
      undemanding taking just 20 s, and results in the formation of multiple 
      hierarchial dendritic structures. To demonstrate that the silver deposition sites 
      were capable of SERS the highly fluorescent Rhodamine 6G (R6G) probe was used. 
      Analyses indicated that Raman enhancement only occurs at the silver deposition 
      sites and not from the roughened copper surface. The robustness of the substrate 
      in the identification and discrimination of illegal and legal drugs of abuse was 
      then explored. Application of the drugs to the substrates was carried out using 
      spotting and soaking methodologies. Whilst little or no SERS spectra of the drugs 
      were generated upon spotting, soaking of the substrate in a methanolic solution 
      of the drugs yielded a vast amount of spectral information. Excellent 
      reproducibility of the SERS method and classification of three of the drugs, 
      4-methylmethcathinone (mephedrone), 5,6-methylenedioxy-2-aminoindane (MDAI) and 
      3,4-methylenedioxy-N-methylamphetamine (MDMA) were demonstrated using principal 
      components analysis and partial least squares.
FAU - Mabbott, Samuel
AU  - Mabbott S
AD  - Manchester Institute of Biotechnology, School of Chemistry, University of 
      Manchester, 131 Princess Street, Manchester, UK.
FAU - Eckmann, Alex
AU  - Eckmann A
FAU - Casiraghi, Cinzia
AU  - Casiraghi C
FAU - Goodacre, Royston
AU  - Goodacre R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121025
PL  - England
TA  - Analyst
JT  - The Analyst
JID - 0372652
RN  - 0 (Fluorescent Dyes)
RN  - 0 (Illicit Drugs)
RN  - 0 (Rhodamines)
RN  - 037VRW83CF (rhodamine 6G)
SB  - IM
MH  - Fluorescent Dyes/chemistry
MH  - Illicit Drugs/*analysis
MH  - Rhodamines/chemistry
MH  - Spectrum Analysis, Raman/*methods
MH  - Surface Properties
EDAT- 2012/10/26 06:00
MHDA- 2014/01/09 06:00
CRDT- 2012/10/26 06:00
PHST- 2012/10/26 06:00 [entrez]
PHST- 2012/10/26 06:00 [pubmed]
PHST- 2014/01/09 06:00 [medline]
AID - 10.1039/c2an35974j [doi]
PST - ppublish
SO  - Analyst. 2013 Jan 7;138(1):118-22. doi: 10.1039/c2an35974j. Epub 2012 Oct 25.