PMID- 23100041
OWN - NLM
STAT- MEDLINE
DCOM- 20130809
LR  - 20220408
IS  - 1536-5166 (Electronic)
IS  - 1070-8022 (Linking)
VI  - 33
IP  - 1
DP  - 2013 Mar
TI  - Retinal nerve fiber layer thickness in Parkinson disease.
PG  - 62-5
LID - 10.1097/WNO.0b013e3182701745 [doi]
AB  - Dopaminergic neuronal cells have been identified in the inner nuclear and inner 
      plexiform layers of the human retina. The dopaminergic content of the retina is 
      reduced in patients with idiopathic Parkinson disease (PD). These observations 
      led us to study the retinal nerve fiber layer (RNFL) thickness in patients with 
      PD without visual impairment compared to healthy controls using spectral-domain 
      optical coherence tomography (SD-OCT). Eighty-two subjects, including 42 patients 
      with PD, newly diagnosed and untreated (24 men, 18 women, age range: 47-66 
      years), and 40 healthy controls, were enrolled. Both eyes of patients with PD and 
      controls were imaged with SD-OCT. The mean RNFL thickness was 77 +/- 11.5 mum in PD 
      patients and 89 +/- 8.7 mum in healthy controls (P = 0.001). Selective thinning of 
      the RNFL was found in the temporal region with mean temporal RNFL thickness of 66 
      +/- 6.7 mum in PD patients and 75 +/- 4.8 mum in controls (P = 0.001). The thickness of 
      the RNFL is decreased in PD patients. Demonstrating progressive thinning of RNFL 
      over time will be critical for validating optical coherence tomography as a 
      viable biomarker of patients with PD.
FAU - Kirbas, Serkan
AU  - Kirbas S
AD  - Department of Neurology, Faculty of Medicine, Rize University, Rize, Turkey. 
      drskirbas@gmail.com
FAU - Turkyilmaz, Kemal
AU  - Turkyilmaz K
FAU - Tufekci, Ahmet
AU  - Tufekci A
FAU - Durmus, Mustafa
AU  - Durmus M
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Neuroophthalmol
JT  - Journal of neuro-ophthalmology : the official journal of the North American 
      Neuro-Ophthalmology Society
JID - 9431308
SB  - IM
MH  - Aged
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Nerve Fibers/*pathology
MH  - Parkinson Disease/*pathology
MH  - Retinal Neurons/*pathology
MH  - Tomography, Optical Coherence
EDAT- 2012/10/27 06:00
MHDA- 2013/08/10 06:00
CRDT- 2012/10/27 06:00
PHST- 2012/10/27 06:00 [entrez]
PHST- 2012/10/27 06:00 [pubmed]
PHST- 2013/08/10 06:00 [medline]
AID - 10.1097/WNO.0b013e3182701745 [doi]
PST - ppublish
SO  - J Neuroophthalmol. 2013 Mar;33(1):62-5. doi: 10.1097/WNO.0b013e3182701745.