PMID- 23100139
OWN - NLM
STAT- MEDLINE
DCOM- 20130605
LR  - 20130102
IS  - 1522-1598 (Electronic)
IS  - 0022-3077 (Linking)
VI  - 109
IP  - 1
DP  - 2013 Jan
TI  - Mechanisms underlying long-interval cortical inhibition in the human motor 
      cortex: a TMS-EEG study.
PG  - 89-98
LID - 10.1152/jn.00762.2012 [doi]
AB  - Long-interval cortical inhibition (LICI) refers to suppression of neuronal 
      activity following paired-pulse transcranial magnetic stimulation (TMS) with 
      interstimulus intervals (ISIs) between 50 and 200 ms. LICI can be measured either 
      from motor-evoked potentials (MEPs) in small hand muscles or directly from the 
      cortex using concurrent electroencephalography (EEG). However, it remains unclear 
      whether EEG inhibition reflects similar mechanisms to MEP inhibition. Eight 
      healthy participants received single- and paired-pulse TMS (ISI = 100 ms) over 
      the motor cortex. MEPs were measured from a small hand muscle (first dorsal 
      interosseus), whereas early (P30, P60) and late (N100) TMS-evoked cortical 
      potentials (TEPs) were measured over the motor cortex using EEG. Conditioning and 
      test TMS intensities were altered, and modulation of LICI strength was measured 
      using both methods. LICI of MEPs and both P30 and P60 TEPs increased in strength 
      with increasing conditioning intensities and decreased with increasing test 
      intensities. LICI of N100 TEPs remained unchanged across all conditions. In 
      addition, MEP and P30 LICI strength correlated with the slope of the N100 evoked 
      by the conditioning pulse. LICI of early and late TEP components was 
      differentially modulated with altered TMS intensities, suggesting independent 
      underlying mechanisms. LICI of P30 is consistent with inhibition of cortical 
      excitation similar to MEPs, whereas LICI of N100 may reflect presynaptic 
      autoinhibition of inhibitory interneurons. The N100 evoked by the conditioning 
      pulse is consistent with the mechanism responsible for LICI, most likely 
      GABA(B)-mediated inhibition of cortical activity.
FAU - Rogasch, Nigel C
AU  - Rogasch NC
AD  - Monash Alfred Psychiatry Research Centre, Alfred and Monash University Central 
      Clinical School, Melbourne, Australia.
FAU - Daskalakis, Zafiris J
AU  - Daskalakis ZJ
FAU - Fitzgerald, Paul B
AU  - Fitzgerald PB
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121024
PL  - United States
TA  - J Neurophysiol
JT  - Journal of neurophysiology
JID - 0375404
SB  - IM
MH  - Adult
MH  - Electroencephalography
MH  - Electromyography
MH  - Evoked Potentials, Motor/*physiology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Motor Cortex/*physiology
MH  - Muscle, Skeletal/*physiology
MH  - Neural Inhibition/*physiology
MH  - Neurons/*physiology
MH  - Reaction Time/physiology
MH  - Transcranial Magnetic Stimulation
EDAT- 2012/10/27 06:00
MHDA- 2013/06/06 06:00
CRDT- 2012/10/27 06:00
PHST- 2012/10/27 06:00 [entrez]
PHST- 2012/10/27 06:00 [pubmed]
PHST- 2013/06/06 06:00 [medline]
AID - jn.00762.2012 [pii]
AID - 10.1152/jn.00762.2012 [doi]
PST - ppublish
SO  - J Neurophysiol. 2013 Jan;109(1):89-98. doi: 10.1152/jn.00762.2012. Epub 2012 Oct 
      24.