PMID- 23101271
OWN - NLM
STAT- MEDLINE
DCOM- 20121205
LR  - 20161021
IS  - 1211-4286 (Print)
IS  - 1211-4286 (Linking)
VI  - 55
IP  - 2
DP  - 2012
TI  - Quantitative analysis of cerebrospinal fluid brain derived neurotrophic factor in 
      the patients with multiple sclerosis.
PG  - 83-6
AB  - Multiple sclerosis (MS) is the most common cause ofnontraumatic neurological 
      disability in Europe and North America. Growth factor expression could 
      participate in the repair process of the demyelinating disease. Among growth 
      factors, brain derived neurotrophic factors (BDNF) has been demonstrated to play 
      an important role in neuronal and axonal survival. In the central nervous system 
      (CNS), neurons are the main source of BDNF. Another potential source are 
      activated astrocytes, which are present in inflamed areas in the CNS as shown in 
      MS. In this study, total protein concentration (TPC) and BDNF levels in the 
      cerebrospinal fluid (CSF) samples from the patients with MS (n = 48) and control 
      subjects (n = 53) were measured using a Bio-Rad protein assay and enzyme linked 
      immunosorbent assay (ELISA). No significant change in the CSF TPC of patients 
      with MS was seen as compared to normal CSF. The presence of BDNF in the CSF 
      samples was shown by Western blot. Using ELISA, it was shown that the level of 
      BDNF in the MS CSF is higher than in normal CSF. It is concluded that BDNF is a 
      constant component of human CSF. Moreover, it could be implicated in the 
      pathophysiology of MS.
FAU - Mashayekhi, Farhad
AU  - Mashayekhi F
AD  - Department of Biology, Islamic Azad University, Tonekabon branch, Tonekabon, 
      Iran. umistbiology@yahoo.co.uk
FAU - Salehi, Zivar
AU  - Salehi Z
FAU - Jamalzadeh, Hamid Reza
AU  - Jamalzadeh HR
LA  - eng
PT  - Journal Article
PL  - Czech Republic
TA  - Acta Medica (Hradec Kralove)
JT  - Acta medica (Hradec Kralove)
JID - 9705947
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Adult
MH  - Brain-Derived Neurotrophic Factor/*cerebrospinal fluid
MH  - Female
MH  - Humans
MH  - Male
MH  - Multiple Sclerosis/*cerebrospinal fluid
EDAT- 2012/10/30 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/10/30 06:00
PHST- 2012/10/30 06:00 [entrez]
PHST- 2012/10/30 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - 10.14712/18059694.2015.60 [doi]
PST - ppublish
SO  - Acta Medica (Hradec Kralove). 2012;55(2):83-6. doi: 10.14712/18059694.2015.60.