PMID- 23103213
OWN - NLM
STAT- MEDLINE
DCOM- 20131017
LR  - 20211021
IS  - 1873-7544 (Electronic)
IS  - 0306-4522 (Print)
IS  - 0306-4522 (Linking)
VI  - 239
DP  - 2013 Jun 3
TI  - Brain-derived neurotrophic factor and androgen interactions in spinal 
      neuromuscular systems.
PG  - 103-14
LID - S0306-4522(12)01043-3 [pii]
LID - 10.1016/j.neuroscience.2012.10.028 [doi]
AB  - Neurotrophic factors and steroid hormones interact to regulate a variety of 
      neuronal processes such as neurite outgrowth, differentiation, and 
      neuroprotection. The coexpression of steroid hormone and neurotrophin receptor 
      mRNAs and proteins, as well as their reciprocal regulation provides the necessary 
      substrates for such interactions to occur. This review will focus on androgen 
      brain-derived neurotrophic factor (BDNF) interactions in the spinal cord, 
      describing androgen regulation of BDNF in neuromuscular systems following 
      castration, androgen manipulation, and injury. Androgens interact with BDNF 
      during development to regulate normally-occurring motoneuron death, and in 
      adulthood, androgen-BDNF interactions are involved in the maintenance of several 
      features of neuromuscular systems. Androgens regulate BDNF and trkB expression in 
      spinal motoneurons. Androgens also regulate BDNF levels in the target 
      musculature, and androgenic action at the muscle regulates BDNF levels in 
      motoneurons. These interactions have important implications for the maintenance 
      of motoneuron morphology. Finally, androgens interact with BDNF after injury, 
      influencing soma size, dendritic morphology, and axon regeneration. Together, 
      these findings provide further insight into the development and maintenance of 
      neuromuscular systems and have implications for the 
      neurotherapeutic/neuroprotective roles of androgens and trophic factors in the 
      treatment of motoneuron disease and recovery from injury.
CI  - Copyright (c) 2012 IBRO. Published by Elsevier Ltd. All rights reserved.
FAU - Verhovshek, T
AU  - Verhovshek T
AD  - Spinal Cord and Brain Injury Research Group, Stark Neurosciences Research 
      Institute and Department of Neurological Surgery, Indiana University School of 
      Medicine, Indianapolis, IN 46202, USA.
FAU - Rudolph, L M
AU  - Rudolph LM
FAU - Sengelaub, D R
AU  - Sengelaub DR
LA  - eng
GR  - R01 NS047264/NS/NINDS NIH HHS/United States
GR  - NS047264/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
DEP - 20121024
PL  - United States
TA  - Neuroscience
JT  - Neuroscience
JID - 7605074
RN  - 0 (Androgens)
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Androgens/*metabolism
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Humans
MH  - Male
MH  - Motor Neurons/metabolism
MH  - Muscle, Skeletal/metabolism
MH  - Neurons/metabolism
MH  - Spinal Cord/*metabolism
PMC - PMC3578168
MID - NIHMS417478
EDAT- 2012/10/30 06:00
MHDA- 2013/10/18 06:00
PMCR- 2014/06/03
CRDT- 2012/10/30 06:00
PHST- 2012/06/28 00:00 [received]
PHST- 2012/08/20 00:00 [revised]
PHST- 2012/10/13 00:00 [accepted]
PHST- 2012/10/30 06:00 [entrez]
PHST- 2012/10/30 06:00 [pubmed]
PHST- 2013/10/18 06:00 [medline]
PHST- 2014/06/03 00:00 [pmc-release]
AID - S0306-4522(12)01043-3 [pii]
AID - 10.1016/j.neuroscience.2012.10.028 [doi]
PST - ppublish
SO  - Neuroscience. 2013 Jun 3;239:103-14. doi: 10.1016/j.neuroscience.2012.10.028. 
      Epub 2012 Oct 24.