PMID- 23103604
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121030
LR  - 20211021
IS  - 2044-6055 (Electronic)
IS  - 2044-6055 (Linking)
VI  - 2
IP  - 5
DP  - 2012
TI  - Adverse events related to intravenous antibiotic therapy: a prospective 
      observational study in the treatment of infective endocarditis.
LID - 10.1136/bmjopen-2012-001189 [doi]
LID - e001189
AB  - OBJECTIVE: The goal of this prospective observational study was to identify 
      adverse events (AEs) related to the use of intravenous access sites used for 
      infective endocarditis (IE) treatment in a tertiary care hospital. DESIGN: This 
      is an observational, analytical and prospective study on AEs resulting from the 
      use of intravenous access sites in patients under antimicrobial treatment for IE. 
      Patients enrolled in the International Collaboration on Endocarditis (ICE) study 
      had their peripheral, short-term central catheters (CVC) and peripherally 
      inserted central catheters (PICC) monitored for AEs. SETTING: Tertiary care 
      hospital for cardiac surgery in Rio de Janeiro, Brazil. PATIENTS: Patients over 
      14 years of age, hospitalised in 2009 and 2010 with possible or definite criteria 
      for IE by the modified Duke criteria were included. MAIN OUTCOME MEASURES: AEs 
      related to intravenous catheters: erythema and infiltration, fever, obstruction, 
      externalisation and blood stream infection. RESULTS: Thirty-seven episodes of IE 
      in 35 patients were studied. Mean patient age was 44.32+/-15.2 years; 22 (63%) were 
      men. The number of vascular catheters studied were 253, 148 of which were 
      peripheral, 85 CVC (21 of which for haemodialysis) and 20 PICC. The most frequent 
      AEs were 'erythema' and 'infiltration' for peripheral catheters, 'fever' for CVCs 
      and 'obstruction' and 'externalisation' for PICCs. The number of catheter-days 
      was 360 for peripheral catheters, 1.156 for CVC and 420 for PICC. Kaplan-Meier 
      curves for CVC and PICC showed statistical difference for obstruction (p<0.001) 
      in PICCs. More bacteraemia occurred in CVC compared with PICC. CONCLUSIONS: The 
      choice of intravenous access sites is critical in the treatment of IE. Close 
      observation for AEs and stricter implementation of infection control measures and 
      better manipulation of catheters are suggested.
FAU - De Paula, Debora Holanda Goncalves
AU  - De Paula DH
AD  - Department of Surgery, Instituto Nacional de Cardiologia, Rio de Janeiro, Brazil.
FAU - Tura, Bernardo Rangel
AU  - Tura BR
FAU - Lamas, Cristiane da Cruz
AU  - Lamas Cda C
LA  - eng
PT  - Journal Article
DEP - 20121026
PL  - England
TA  - BMJ Open
JT  - BMJ open
JID - 101552874
PMC - PMC3534239
EDAT- 2012/10/30 06:00
MHDA- 2012/10/30 06:01
PMCR- 2012/10/26
CRDT- 2012/10/30 06:00
PHST- 2012/10/30 06:00 [entrez]
PHST- 2012/10/30 06:00 [pubmed]
PHST- 2012/10/30 06:01 [medline]
PHST- 2012/10/26 00:00 [pmc-release]
AID - bmjopen-2012-001189 [pii]
AID - 10.1136/bmjopen-2012-001189 [doi]
PST - epublish
SO  - BMJ Open. 2012 Oct 26;2(5):e001189. doi: 10.1136/bmjopen-2012-001189. Print 2012.