PMID- 23104086
OWN - NLM
STAT- MEDLINE
DCOM- 20130913
LR  - 20211021
IS  - 1573-4838 (Electronic)
IS  - 0957-4530 (Linking)
VI  - 24
IP  - 2
DP  - 2013 Feb
TI  - Development of pH-sensitive pectinate/alginate microspheres for colon drug 
      delivery.
PG  - 317-23
LID - 10.1007/s10856-012-4798-9 [doi]
AB  - The purposes of this study were to develop and evaluate calcium 
      pectinate/alginate microspheres (PAMs) and to exploit their pH-sensitive 
      properties for colon-targeted delivery of encapsulated cisplatin. PAMs were 
      prepared using an electrospraying method. The PAMs, as cores, were then coated 
      with Eudragit S100 using a polyelectrolyte multilayer coating technique in 
      aqueous solution. The morphology of the microspheres was observed under scanning 
      electron microscopy. In vitro drug release studies were performed in simulated 
      gastrointestinal fluid, and the results indicated that approximately 5 % of the 
      cisplatin was released from the Eudragit S100-coated PAMs, and 51 % of the 
      cisplatin was released from the uncoated PAMs at 1 h. The release of cisplatin 
      from the Eudragit S100-coated PAMs was more sustained in simulated gastric fluid 
      than in simulated intestinal fluid due to the increased solubility of the coating 
      polymer in media with pH >7.0. Drug release from the Eudragit S100-coated PAMs 
      was best described by the Higuchi's square root model. From these results, it was 
      concluded that Eudragit S100-coated PAMs are a potential carrier for delivery of 
      cisplatin to the colon.
FAU - Hsu, Fu-Yin
AU  - Hsu FY
AD  - Department of Life Sciences, National Taiwan Ocean University, Keelung, Taiwan, 
      ROC. fyhsu5565@gmail.com
FAU - Yu, Ding-Syuan
AU  - Yu DS
FAU - Huang, Chun-Chiang
AU  - Huang CC
LA  - eng
PT  - Journal Article
DEP - 20121027
PL  - United States
TA  - J Mater Sci Mater Med
JT  - Journal of materials science. Materials in medicine
JID - 9013087
RN  - 0 (Alginates)
RN  - 0 (Coated Materials, Biocompatible)
RN  - 0 (Drug Carriers)
RN  - 0 (Excipients)
RN  - 0 (Hexuronic Acids)
RN  - 0 (Polymethacrylic Acids)
RN  - 25086-15-1 (methylmethacrylate-methacrylic acid copolymer)
RN  - 89NA02M4RX (Pectins)
RN  - 8A5D83Q4RW (Glucuronic Acid)
RN  - Q20Q21Q62J (Cisplatin)
SB  - IM
MH  - Alginates/chemical synthesis/*chemistry
MH  - Cisplatin/*administration & dosage/pharmacokinetics
MH  - Coated Materials, Biocompatible/chemical synthesis/chemistry
MH  - *Colon/metabolism
MH  - Drug Carriers/analysis/chemical synthesis/chemistry
MH  - *Drug Delivery Systems/methods
MH  - Excipients/analysis/chemistry
MH  - Gastrointestinal Contents
MH  - Glucuronic Acid/chemical synthesis/chemistry
MH  - Hexuronic Acids/chemical synthesis/chemistry
MH  - Humans
MH  - Hydrogen-Ion Concentration
MH  - Materials Testing
MH  - *Microspheres
MH  - Particle Size
MH  - Pectins/chemical synthesis/*chemistry
MH  - Polymethacrylic Acids/chemistry
MH  - Solubility
EDAT- 2012/10/30 06:00
MHDA- 2013/09/14 06:00
CRDT- 2012/10/30 06:00
PHST- 2012/07/03 00:00 [received]
PHST- 2012/10/15 00:00 [accepted]
PHST- 2012/10/30 06:00 [entrez]
PHST- 2012/10/30 06:00 [pubmed]
PHST- 2013/09/14 06:00 [medline]
AID - 10.1007/s10856-012-4798-9 [doi]
PST - ppublish
SO  - J Mater Sci Mater Med. 2013 Feb;24(2):317-23. doi: 10.1007/s10856-012-4798-9. 
      Epub 2012 Oct 27.