PMID- 23104857
OWN - NLM
STAT- MEDLINE
DCOM- 20130531
LR  - 20121029
IS  - 1532-2092 (Electronic)
IS  - 1099-5129 (Linking)
VI  - 14
IP  - 11
DP  - 2012 Nov
TI  - Effect of cardiac resynchronization therapy and implantable cardioverter 
      defibrillator on quality of life in patients with heart failure: a meta-analysis.
PG  - 1602-7
LID - 10.1093/europace/eus168 [doi]
AB  - AIMS: To compare the improvement of quality of life (QoL) in cardiac 
      resynchronization therapy plus implantable cardioverter defibrillator (CRT-D) 
      therapy with that in implantable cardioverter defibrillator (ICD) therapy alone 
      for patients with heart failure. METHODS AND RESULTS: Medline, Embase, The 
      Cochrane Library, and US Food and Drug Administration website were searched for 
      published studies up to 31 December 2011. Studies were considered for inclusion 
      if they were randomized controlled trials (RCTs) that compared the efficacy of 
      CRT-D therapy with ICD therapy in patients with heart failure. The primary 
      outcome of this study was improvement in QoL. Four RCTs with 1655 patients were 
      included in this meta-analysis. Overall, the QoL score of patients in CRT-D group 
      significantly improved [weighted mean difference (WMD): -6.02; 95% confidence 
      interval (CI): -10.56 to -1.48] compared with that in the ICD only group. 
      However, the benefit with respect to QoL in CRT-D group was not maintained when 
      subset meta-analysis was performed in patients with New York Heart Association 
      (NYHA) class I-II (WMD: 0.19; 95% CI: -3.89 to 4.72), whereas the patients with 
      NYHA class III-IV in CRT-D group still experienced a significant improvement of 
      QoL score compared with ICD group (WMD: -8.49; 95% CI: -13.39 to -3.59). 
      CONCLUSIONS: CRT-D therapy improves the QoL compared with ICD therapy alone, 
      especially in patients with moderate to severe heart failure.
FAU - Chen, Shaojie
AU  - Chen S
AD  - Department of Cardiology, The Second Affiliated Hospital of Chongqing Medical 
      University, Chongqing 400010, China.
FAU - Yin, Yuehui
AU  - Yin Y
FAU - Krucoff, Mitchell W
AU  - Krucoff MW
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
PL  - England
TA  - Europace
JT  - Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal 
      of the working groups on cardiac pacing, arrhythmias, and cardiac cellular 
      electrophysiology of the European Society of Cardiology
JID - 100883649
SB  - IM
CIN - Europace. 2012 Nov;14(11):1537-9. PMID: 23099426
MH  - *Cardiac Resynchronization Therapy/adverse effects
MH  - *Cardiac Resynchronization Therapy Devices/adverse effects
MH  - *Defibrillators, Implantable/adverse effects
MH  - Electric Countershock/adverse effects/*instrumentation
MH  - Heart Failure/diagnosis/physiopathology/psychology/*therapy
MH  - Humans
MH  - *Quality of Life
MH  - Randomized Controlled Trials as Topic
MH  - Severity of Illness Index
MH  - Treatment Outcome
EDAT- 2012/10/30 06:00
MHDA- 2013/06/01 06:00
CRDT- 2012/10/30 06:00
PHST- 2012/10/30 06:00 [entrez]
PHST- 2012/10/30 06:00 [pubmed]
PHST- 2013/06/01 06:00 [medline]
AID - eus168 [pii]
AID - 10.1093/europace/eus168 [doi]
PST - ppublish
SO  - Europace. 2012 Nov;14(11):1602-7. doi: 10.1093/europace/eus168.