PMID- 23105236 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20121030 LR - 20240505 IS - 0970-1915 (Print) IS - 0974-0422 (Electronic) IS - 0970-1915 (Linking) VI - 15 IP - 1 DP - 2000 Aug TI - Preliminary study on circulating serum levels of tumor necrosis factor-Alpha in patients of tuberculosis. PG - 40-3 LID - 10.1007/BF02873546 [doi] AB - Tumor necrosis factor-alpha (TNF-alpha) has been implicated in the pathogenesis of several non-infectious and infectious diseases including tuberculosis. In a prospective longitudinal study, TNF-alpha level in blood was estimated by sandwich ELISA using anti human TNF-alpha antibody, in 22 patients with active pleuro-pulmonary and lymphnode tuberculosis before and after chemotherapy and 8 healthy controls. Six patients and six controls had detectable levels (> 5 pg/ml) of TNF-alpha in blood. The mean TNF-alpha levels in controls and cases before and after treatment were 182.4pg/ml, 896.7 pg/ml and 678.7pg/ml pg/ml respectively. Though not statistically significant, there was a trend towards younger age, shorter duration of symptoms, presence of fever and anorexia, and high ESR, in patient with high serum TNF-alpha levels. FAU - Gupta, R AU - Gupta R AD - Department of Medicine, All India Institute of Medical Sciences, 110029 New Delhi. FAU - Prasad, H K AU - Prasad HK FAU - Nagarkar, K M AU - Nagarkar KM FAU - Dey, A B AU - Dey AB LA - eng PT - Journal Article PL - India TA - Indian J Clin Biochem JT - Indian journal of clinical biochemistry : IJCB JID - 8708303 PMC - PMC3453539 OTO - NOTNLM OT - Tumor necrosis factor OT - cytokines OT - tuberculosis EDAT- 2000/08/01 00:00 MHDA- 2000/08/01 00:01 PMCR- 2001/08/01 CRDT- 2012/10/30 06:00 PHST- 2012/10/30 06:00 [entrez] PHST- 2000/08/01 00:00 [pubmed] PHST- 2000/08/01 00:01 [medline] PHST- 2001/08/01 00:00 [pmc-release] AID - BF02873546 [pii] AID - 10.1007/BF02873546 [doi] PST - ppublish SO - Indian J Clin Biochem. 2000 Aug;15(1):40-3. doi: 10.1007/BF02873546.