PMID- 23105635
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121030
LR  - 20211021
IS  - 0970-1915 (Print)
IS  - 0974-0422 (Electronic)
IS  - 0970-1915 (Linking)
VI  - 21
IP  - 2
DP  - 2006 Sep
TI  - Defect in mitochondrial functions in damaged human mitral valve.
PG  - 156-60
LID - 10.1007/BF02912933 [doi]
AB  - Mitochondrial diseases are a heterogeneous group of disorders in which a primary 
      mitochondrial dysfunction is proven by morphological, biochemical, and genetic 
      examinations. The mitral valve has important function in the regulation of blood 
      flow from one chamber to another. Often, the mitral valve becomes abnormal with 
      age, in Rheumatic fever or it is abnormal from birth (Congenital) or it can be 
      destroyed by infection i.e. bacterial endocarditis and needs replacement. 
      Myocardial function depends on energy produced by mitochondria and in any of 
      these disease conditions, mitochondrial functions and enzyme activities may be 
      impaired. With this in view, we analyzed the relationship between preoperative 
      clinical conditions (as per New York heart Association) and extent of 
      mitochondrial enzyme activities in damaged Human mitral valve in two types of 
      heart disease such as Rheumatic Heart Disease (RHD) and Bacterial Endocarditis 
      (BE). Thirty nine Patients undergoing cardiopulmonary bypass (CPB) for routine 
      valvular heart surgery were included in the study. Controls included 11 normal 
      porcine mitral valve samples without any evidence of heart disease. Mitochondrial 
      enzymes like cytochrome oxidase (COX), succinate dehydrogenase (SDH), malate 
      dehydrogenase (MDH), citrate synthase (CS) and ATPase were determined. 
      Mitochondrial COX, SDH, CS and Total ATPase activities were significantly 
      decreased in disease condition like BE and RHD when compared with control 
      (P<0.001). On the other hand as per New York Heart Association (NYHA) 
      preoperative clinical classification, all the mitochondrial enzymes were 
      significantly (p<0.05) impaired in class IV as compared with NYHA class I, II and 
      III. Present study shows that impairment in the mitochondrial enzymes activities 
      are more pronounced in bacterial endocarditis (BE). It also indicates that damage 
      to mitochondrial enzymes are most pronounced in NYHA class IV.
FAU - Shinde, Santosh
AU  - Shinde S
AD  - Department of Biochemistry, L.T.M.M.C and L.T.M.G.H., 400025 Mumbai, India.
FAU - Kumar, Pawan
AU  - Kumar P
FAU - Mishra, Kaushala
AU  - Mishra K
FAU - Patil, Neela
AU  - Patil N
LA  - eng
PT  - Journal Article
PL  - India
TA  - Indian J Clin Biochem
JT  - Indian journal of clinical biochemistry : IJCB
JID - 8708303
PMC - PMC3453995
OTO - NOTNLM
OT  - Human heart
OT  - Mital valve
OT  - and Mitochondrial functions
EDAT- 2006/09/01 00:00
MHDA- 2006/09/01 00:01
PMCR- 2007/09/01
CRDT- 2012/10/30 06:00
PHST- 2012/10/30 06:00 [entrez]
PHST- 2006/09/01 00:00 [pubmed]
PHST- 2006/09/01 00:01 [medline]
PHST- 2007/09/01 00:00 [pmc-release]
AID - BF02912933 [pii]
AID - 10.1007/BF02912933 [doi]
PST - ppublish
SO  - Indian J Clin Biochem. 2006 Sep;21(2):156-60. doi: 10.1007/BF02912933.