PMID- 23105899
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121030
LR  - 20211021
IS  - 0970-1915 (Print)
IS  - 0974-0422 (Electronic)
IS  - 0970-1915 (Linking)
VI  - 25
IP  - 2
DP  - 2010 Apr
TI  - Matrix metalloproteinase-3 (MMP-3) -1612 5A/6A promoter polymorphism in coronary 
      artery disease in Indian population.
PG  - 133-40
LID - 10.1007/s12291-010-0025-y [doi]
AB  - Matrix metalloproteinases (MMPs) play important role in the pathogenesis of 
      coronary artery disease (CAD). 5A allele of -1612 5A/6A polymorphism of MMP-3 is 
      associated with two fold higher activity than 6A allele. Present study was 
      designed to analyse the association of this polymorphism with CAD in Indian 
      population. Subjects included in the study were patients with stable angina 
      (n=35), unstable angina (n=53), patients with recent event of myocardial 
      infarction (MI) (MI Group-1, n=56) and patients at presentation of the acute MI 
      (MI Group-2, n=49). Controls were healthy individuals (n=99). Genotyping of MMP-3 
      5A/6A polymorphism was carried out by PCR-based restriction digestion method. The 
      genotype distribution of patient groups did not deviate from controls. Serum 
      MMP-3 levels were significantly elevated at presentation of the acute MI by 36.8% 
      (P=0.031) as compared to controls and more associated with 6A genotype suggesting 
      discrepancy between in vitro transfection experiment and peripheral MMP-3 levels.
FAU - Shalia, Kavita K
AU  - Shalia KK
AD  - Sir H. N. Medical Research Society, Sir H. N. Hospital and Research Centre, Raja 
      Rammohan Roy Road, Mumbai, 400 004 India.
FAU - Shah, V K
AU  - Shah VK
FAU - Mashru, M R
AU  - Mashru MR
FAU - Soneji, S L
AU  - Soneji SL
FAU - Vasvani, J B
AU  - Vasvani JB
FAU - Payannavar, S
AU  - Payannavar S
FAU - Walvalkar, A
AU  - Walvalkar A
FAU - Mokal, R
AU  - Mokal R
FAU - Mithbawkar, S S
AU  - Mithbawkar SS
FAU - Bootwalla, M
AU  - Bootwalla M
FAU - Sadvekar, P
AU  - Sadvekar P
FAU - Thakur, P K
AU  - Thakur PK
LA  - eng
PT  - Journal Article
DEP - 20100527
PL  - India
TA  - Indian J Clin Biochem
JT  - Indian journal of clinical biochemistry : IJCB
JID - 8708303
PMC - PMC3453096
OTO - NOTNLM
OT  - Coronary artery disease
OT  - Matrix metalloproteinase-3
OT  - Myocardial infarction
OT  - Single nucleotide polymorphism
OT  - Stable angina
OT  - Unstable angina
EDAT- 2010/04/01 00:00
MHDA- 2010/04/01 00:01
PMCR- 2011/04/01
CRDT- 2012/10/30 06:00
PHST- 2012/10/30 06:00 [entrez]
PHST- 2010/04/01 00:00 [pubmed]
PHST- 2010/04/01 00:01 [medline]
PHST- 2011/04/01 00:00 [pmc-release]
AID - 25 [pii]
AID - 10.1007/s12291-010-0025-y [doi]
PST - ppublish
SO  - Indian J Clin Biochem. 2010 Apr;25(2):133-40. doi: 10.1007/s12291-010-0025-y. 
      Epub 2010 May 27.