PMID- 23107451
OWN - NLM
STAT- MEDLINE
DCOM- 20130402
LR  - 20240117
IS  - 1532-429X (Electronic)
IS  - 1097-6647 (Print)
IS  - 1097-6647 (Linking)
VI  - 14
IP  - 1
DP  - 2012 Oct 29
TI  - Diffuse myocardial fibrosis in hypertrophic cardiomyopathy can be identified by 
      cardiovascular magnetic resonance, and is associated with left ventricular 
      diastolic dysfunction.
PG  - 76
LID - 10.1186/1532-429X-14-76 [doi]
AB  - BACKGROUND: The presence of myocardial fibrosis is associated with worse clinical 
      outcomes in hypertrophic cardiomyopathy (HCM). Cardiovascular magnetic resonance 
      (CMR) with late gadolinium enhancement (LGE) sequences can detect regional, but 
      not diffuse myocardial fibrosis. Post-contrast T(1) mapping is an emerging CMR 
      technique that may enable the non-invasive evaluation of diffuse myocardial 
      fibrosis in HCM. The purpose of this study was to non-invasively detect and 
      quantify diffuse myocardial fibrosis in HCM with CMR and examine its relationship 
      to diastolic performance. METHODS: We performed CMR on 76 patients - 51 with 
      asymmetric septal hypertrophy due to HCM and 25 healthy controls. Left 
      ventricular (LV) morphology, function and distribution of regional myocardial 
      fibrosis were evaluated with cine imaging and LGE. A CMR T(1) mapping sequence 
      determined the post-contrast myocardial T(1) time as an index of diffuse 
      myocardial fibrosis. Diastolic function was assessed by transthoracic 
      echocardiography. RESULTS: Regional myocardial fibrosis was observed in 84% of 
      the HCM group. Post-contrast myocardial T(1) time was significantly shorter in 
      patients with HCM compared to controls, consistent with diffuse myocardial 
      fibrosis (498 +/- 80 ms vs. 561 +/- 47 ms, p < 0.001). In HCM patients, post-contrast 
      myocardial T(1) time correlated with mean E/e' (r = -0.48, p < 0.001). 
      CONCLUSIONS: Patients with HCM have shorter post-contrast myocardial T(1) times, 
      consistent with diffuse myocardial fibrosis, which correlate with estimated LV 
      filling pressure, suggesting a mechanistic link between diffuse myocardial 
      fibrosis and abnormal diastolic function in HCM.
FAU - Ellims, Andris H
AU  - Ellims AH
AD  - Heart Centre, Alfred Hospital, Melbourne, Australia.
FAU - Iles, Leah M
AU  - Iles LM
FAU - Ling, Liang-han
AU  - Ling LH
FAU - Hare, James L
AU  - Hare JL
FAU - Kaye, David M
AU  - Kaye DM
FAU - Taylor, Andrew J
AU  - Taylor AJ
LA  - eng
PT  - Journal Article
DEP - 20121029
PL  - England
TA  - J Cardiovasc Magn Reson
JT  - Journal of cardiovascular magnetic resonance : official journal of the Society 
      for Cardiovascular Magnetic Resonance
JID - 9815616
RN  - 0 (Contrast Media)
RN  - K2I13DR72L (Gadolinium DTPA)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Cardiomyopathy, Hypertrophic/complications/*diagnosis/diagnostic 
      imaging/pathology/physiopathology
MH  - Case-Control Studies
MH  - Chi-Square Distribution
MH  - Contrast Media
MH  - *Diastole
MH  - Female
MH  - Fibrosis
MH  - Gadolinium DTPA
MH  - Humans
MH  - Linear Models
MH  - *Magnetic Resonance Imaging, Cine
MH  - Male
MH  - Middle Aged
MH  - Myocardium/*pathology
MH  - Predictive Value of Tests
MH  - Stroke Volume
MH  - Time Factors
MH  - Ultrasonography
MH  - Ventricular Dysfunction, Left/*diagnosis/diagnostic 
      imaging/etiology/pathology/*physiopathology
MH  - *Ventricular Function, Left
PMC - PMC3502601
EDAT- 2012/10/31 06:00
MHDA- 2013/04/03 06:00
PMCR- 2012/10/29
CRDT- 2012/10/31 06:00
PHST- 2012/07/11 00:00 [received]
PHST- 2012/10/17 00:00 [accepted]
PHST- 2012/10/31 06:00 [entrez]
PHST- 2012/10/31 06:00 [pubmed]
PHST- 2013/04/03 06:00 [medline]
PHST- 2012/10/29 00:00 [pmc-release]
AID - S1097-6647(23)00696-8 [pii]
AID - 1532-429X-14-76 [pii]
AID - 10.1186/1532-429X-14-76 [doi]
PST - epublish
SO  - J Cardiovasc Magn Reson. 2012 Oct 29;14(1):76. doi: 10.1186/1532-429X-14-76.