PMID- 23108259
OWN - NLM
STAT- MEDLINE
DCOM- 20130930
LR  - 20171116
IS  - 1423-0399 (Electronic)
IS  - 0042-1138 (Linking)
VI  - 90
IP  - 2
DP  - 2013
TI  - Primitive neuroectodermal tumor of the kidney: a single-institute series of six 
      patients from China.
PG  - 174-8
LID - 10.1159/000342647 [doi]
AB  - OBJECTIVE: Renal primitive neuroectodermal tumor (PNET) is a rare and highly 
      malignant neoplasm. Our study aims to present the clinical findings and prognosis 
      of 6 patients with renal PNET from China. MATERIAL AND METHODS: From January 2003 
      to February 2012, 6 patients with renal PNET confirmed by immunohistochemical 
      staining and fluorescence in situ hybridization (FISH) treated in our institution 
      were reviewed retrospectively and our data compared with the literature. RESULTS: 
      There were 4 male and 2 female patients with a mean age of 35.0 years. The mean 
      diameter was 13.3 cm. Five of the masses had renal vein thrombosis, and 3 
      extended into the inferior vena cava. A lymph node metastasis was detected in 1 
      patient and a liver metastasis in another patient. Radical nephrectomy was 
      performed in all cases, with 5 patients following chemotherapy and 1 receiving 
      Sutent treatment. Within a median follow-up of 7.5 months (range 1-71), median 
      overall survival was 22.1 months. CONCLUSIONS: The diagnosis of renal PNET should 
      be considered in young patients presenting with renal mass and venous thrombosis. 
      It seems that Asian renal PNET patients had a higher rate of venous thrombosis 
      than Caucasian populations. CD99 positivity on immunohistochemistry and EWS-FL1 
      chimera gene detected by FISH support the diagnosis. The prognosis is poor 
      despite multimodal treatment.
CI  - Copyright (c) 2012 S. Karger AG, Basel.
FAU - Huang, Jiwei
AU  - Huang J
AD  - Department of Urology, Renji Hospital Affiliated to Shanghai Jiao Tong University 
      School of Medicine, Shanghai, PR China.
FAU - Zhang, Jin
AU  - Zhang J
FAU - Dong, Baijun
AU  - Dong B
FAU - Chen, Yonghui
AU  - Chen Y
FAU - Kong, Wen
AU  - Kong W
FAU - Liu, Qiang
AU  - Liu Q
FAU - Xue, Wei
AU  - Xue W
FAU - Liu, Dongming
AU  - Liu D
FAU - Huang, Yiran
AU  - Huang Y
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121026
PL  - Switzerland
TA  - Urol Int
JT  - Urologia internationalis
JID - 0417373
RN  - 0 (12E7 Antigen)
RN  - 0 (Antigens, CD)
RN  - 0 (CD99 protein, human)
RN  - 0 (Cell Adhesion Molecules)
RN  - 0 (EWS-FLI fusion protein)
RN  - 0 (Oncogene Proteins, Fusion)
RN  - 0 (Proto-Oncogene Protein c-fli-1)
RN  - 0 (RNA-Binding Protein EWS)
SB  - IM
MH  - 12E7 Antigen
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Antigens, CD/metabolism
MH  - Cell Adhesion Molecules/metabolism
MH  - China
MH  - Female
MH  - Humans
MH  - Kidney Neoplasms/*diagnosis/mortality/therapy
MH  - Lymphatic Metastasis
MH  - Male
MH  - Middle Aged
MH  - Neuroectodermal Tumors, Primitive/*diagnosis/mortality/therapy
MH  - Oncogene Proteins, Fusion/metabolism
MH  - Prognosis
MH  - Proto-Oncogene Protein c-fli-1/metabolism
MH  - RNA-Binding Protein EWS/metabolism
MH  - Renal Veins/physiopathology
MH  - Retrospective Studies
MH  - Treatment Outcome
MH  - Vena Cava, Inferior/physiopathology
MH  - Venous Thrombosis/complications
MH  - Young Adult
EDAT- 2012/10/31 06:00
MHDA- 2013/10/01 06:00
CRDT- 2012/10/31 06:00
PHST- 2012/05/07 00:00 [received]
PHST- 2012/08/02 00:00 [accepted]
PHST- 2012/10/31 06:00 [entrez]
PHST- 2012/10/31 06:00 [pubmed]
PHST- 2013/10/01 06:00 [medline]
AID - 000342647 [pii]
AID - 10.1159/000342647 [doi]
PST - ppublish
SO  - Urol Int. 2013;90(2):174-8. doi: 10.1159/000342647. Epub 2012 Oct 26.