PMID- 23108906
OWN - NLM
STAT- MEDLINE
DCOM- 20140714
LR  - 20210208
IS  - 1097-0347 (Electronic)
IS  - 1043-3074 (Linking)
VI  - 35
IP  - 11
DP  - 2013 Nov
TI  - p16 expression in cutaneous squamous carcinomas with neck metastases: a potential 
      pitfall in identifying unknown primaries of the head and neck.
PG  - 1527-33
LID - 10.1002/hed.23188 [doi]
AB  - BACKGROUND: Human papillomavirus (HPV) positivity (+) has been used to identify 
      oropharyngeal squamous carcinomas (SCCs) presenting as unknown primaries in the 
      neck. p16 overexpression correlates with HPV+ in the oropharynx; however, the use 
      of p16 alone as a surrogate marker of oropharyngeal HPV+ tumors has not been 
      validated. METHODS: We immunohistochemically analyzed p16 expression in 
      surgically resected aggressive cutaneous head and neck SCC primaries and their 
      nodal metastases from 24 patients to determine the potential overlap of p16 
      expression outside of the oropharynx. RESULTS: Five of 24 primary tumors (20.8%) 
      and 3 lymph node metastases (12.5%) in levels II, III, and V, and the periparotid 
      region diffusely expressed p16. HPV (high-risk types by in situ hybridization) 
      was negative. CONCLUSIONS: p16 expression is relatively common in lymph 
      node-positive cutaneous head and neck SCCs; thus, p16 expression as an 
      independent biomarker and mechanism to determine the oropharyngeal source of an 
      unknown primary is not advised.
CI  - Copyright (c) 2012 Wiley Periodicals, Inc.
FAU - Beadle, Beth M
AU  - Beadle BM
AD  - Department of Radiation Oncology, The University of Texas MD Anderson Cancer 
      Center, Houston, Texas.
FAU - William, William N Jr
AU  - William WN Jr
FAU - McLemore, Michael S
AU  - McLemore MS
FAU - Sturgis, Erich M
AU  - Sturgis EM
FAU - Williams, Michelle D
AU  - Williams MD
LA  - eng
PT  - Journal Article
DEP - 20121029
PL  - United States
TA  - Head Neck
JT  - Head & neck
JID - 8902541
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (CDKN2A protein, human)
RN  - 0 (Cyclin-Dependent Kinase Inhibitor p16)
RN  - 0 (Neoplasm Proteins)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Biomarkers, Tumor/*analysis
MH  - Biopsy, Needle
MH  - Carcinoma, Squamous Cell/*chemistry/mortality/*secondary
MH  - Cyclin-Dependent Kinase Inhibitor p16
MH  - Databases, Factual
MH  - Disease-Free Survival
MH  - Female
MH  - Head and Neck Neoplasms/chemistry/mortality/secondary/virology
MH  - Human papillomavirus 16/genetics/isolation & purification
MH  - Humans
MH  - Immunohistochemistry
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Proteins/*analysis
MH  - Neoplasms, Unknown Primary/*chemistry/mortality/pathology/virology
MH  - Oropharyngeal Neoplasms/chemistry/mortality/*secondary/virology
MH  - Papillomavirus Infections/genetics/pathology
MH  - Prognosis
MH  - Retrospective Studies
MH  - Risk Assessment
MH  - Skin Neoplasms/*chemistry/mortality/pathology
MH  - Survival Analysis
OTO - NOTNLM
OT  - cutaneous squamous carcinoma
OT  - neck metastases
OT  - p16
OT  - unknown primary
EDAT- 2012/10/31 06:00
MHDA- 2014/07/16 06:00
CRDT- 2012/10/31 06:00
PHST- 2012/09/12 00:00 [accepted]
PHST- 2012/10/31 06:00 [entrez]
PHST- 2012/10/31 06:00 [pubmed]
PHST- 2014/07/16 06:00 [medline]
AID - 10.1002/hed.23188 [doi]
PST - ppublish
SO  - Head Neck. 2013 Nov;35(11):1527-33. doi: 10.1002/hed.23188. Epub 2012 Oct 29.