PMID- 23110273
OWN - NLM
STAT- MEDLINE
DCOM- 20121218
LR  - 20121030
IS  - 1064-6655 (Print)
IS  - 1064-6655 (Linking)
VI  - 26
IP  - 4
DP  - 2012 Fall
TI  - Effect of estrogen and dietary loading on condylar cartilage.
PG  - 328-36
AB  - AIMS: To study the effect of estrogen deficiency and altered temporomandibular 
      joint loading on the histomorphology of condylar cartilage and on the expression 
      of types II and X collagen and matrix metalloproteinase-3 (MMP-3). METHODS: 
      Thirty-six female rats were divided into four groups: ovariectomized rats on a 
      normal diet, nonovariectomized control rats on a normal diet, ovariectomized rats 
      on a soft diet, and nonovariectomized control rats on a soft diet. Ovariectomy 
      was performed at the age of 60 days. Repeated-measures ANOVA was used to analyze 
      the data. RESULTS: The condylar cartilage in the ovariectomized normal diet group 
      showed a significantly higher number of cells than in the nonovariectomized 
      control rats (P < .001). The proportional amount of MMP-3 expression was 
      significantly higher in the ovariectomized rats than in the nonovariectomized 
      control rats in both diet groups (P < .001). The area covered by types II and X 
      collagen was significantly higher in the experimental groups than in the control 
      groups (P < .01). CONCLUSION: Condylar cartilage is sensitive to both estrogen 
      level and dietary loading.
FAU - Orajarvi, Marko
AU  - Orajarvi M
AD  - Department of Prosthetic Dentistry and Stomatognatic Physiology.
FAU - Puijola, Elina
AU  - Puijola E
FAU - Yu, Shi-Bin
AU  - Yu SB
FAU - Liu, Xiaodong
AU  - Liu X
FAU - Tiilikainen, Petri
AU  - Tiilikainen P
FAU - Wang, Meiqing
AU  - Wang M
FAU - Raustia, Aune
AU  - Raustia A
FAU - Pirttiniemi, Pertti
AU  - Pirttiniemi P
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Orofac Pain
JT  - Journal of orofacial pain
JID - 9418507
RN  - 0 (Collagen Type II)
RN  - 0 (Collagen Type X)
RN  - 0 (Estrogens)
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
MH  - Animals
MH  - Cartilage, Articular/metabolism/*pathology
MH  - Chondrocytes/metabolism
MH  - Collagen Type II/*biosynthesis
MH  - Collagen Type X/*biosynthesis
MH  - Dental Stress Analysis
MH  - Diet
MH  - Estrogens/*deficiency
MH  - Female
MH  - Mandibular Condyle/*physiopathology
MH  - Mastication/physiology
MH  - Matrix Metalloproteinase 3/*biosynthesis
MH  - Ovariectomy
MH  - Rats
MH  - Temporomandibular Joint/*physiology
EDAT- 2012/10/31 06:00
MHDA- 2012/12/19 06:00
CRDT- 2012/10/31 06:00
PHST- 2012/10/31 06:00 [entrez]
PHST- 2012/10/31 06:00 [pubmed]
PHST- 2012/12/19 06:00 [medline]
PST - ppublish
SO  - J Orofac Pain. 2012 Fall;26(4):328-36.