PMID- 23110545
OWN - NLM
STAT- MEDLINE
DCOM- 20131105
LR  - 20220311
IS  - 1365-2060 (Electronic)
IS  - 0785-3890 (Print)
IS  - 0785-3890 (Linking)
VI  - 45
IP  - 3
DP  - 2013 May
TI  - Immunoglobulin E and mast cell proteases are potential risk factors of impaired 
      fasting glucose and impaired glucose tolerance in humans.
PG  - 220-9
LID - 10.3109/07853890.2012.732234 [doi]
AB  - AIM: Mast cells are important in experimental diabetes. Plasma levels of 
      immunoglobulin E (IgE), tryptases, and chymases are inflammatory markers of human 
      diabetes. Whether they also correlate with the risk of pre-diabetes, however, 
      remains unknown. METHODS AND RESULTS: A total of 260 subjects 55-75 years of age 
      were grouped as normal glucose tolerance (NGT), isolated impaired fasting glucose 
      (I-IFG), isolated impaired glucose tolerance (I-IGT), and mixed IFG/IGT. There 
      were significant differences in plasma levels of high-sensitivity C-reactive 
      protein (hsCRP) (P < 0.001) and IgE (P = 0.003) among all subgroups of 
      pre-diabetes, and chymase in I-IGT (P = 0.043) and mixed IFG/IGT (P = 0.037) 
      subgroups compared with NGT group. High-sensitivity CRP was a risk factor in all 
      subgroups of pre-diabetes; IgE was a risk factor of mixed IFG/IGT; and chymase 
      was a risk factor of I-IGT and mixed IFG/IGT. Interactions between hsCRP and high 
      waist circumference (WC), waist-to-hip ratio (WHR), or HOMA-beta index, and 
      interactions between IgE and high WC or tryptase levels all increased further the 
      risk of developing I-IFG, I-IGT, or mixed IFG/IGT. CONCLUSION: Plasma hsCRP, IgE, 
      and chymase levels associate with pre-diabetes status. While hsCRP, IgE, and 
      chymase are individual risk factors of pre-diabetes, interactions with metabolic 
      parameters increased further the risk of pre-diabetes.
FAU - Wang, Zhen
AU  - Wang Z
AD  - Department of Clinical Medicine, School of Medicine, Huzhou Teachers College , 
      Huzhou, 313000, Zhejiang , China.
FAU - Zhang, Hong
AU  - Zhang H
FAU - Shen, Xu-Hui
AU  - Shen XH
FAU - Jin, Kui-Li
AU  - Jin KL
FAU - Ye, Guo-Fen
AU  - Ye GF
FAU - Qiu, Wei
AU  - Qiu W
FAU - Qian, Li
AU  - Qian L
FAU - Li, Bo
AU  - Li B
FAU - Zhang, Yong-Hong
AU  - Zhang YH
FAU - Shi, Guo-Ping
AU  - Shi GP
LA  - eng
GR  - R01 HL060942/HL/NHLBI NIH HHS/United States
GR  - R01 HL081090/HL/NHLBI NIH HHS/United States
GR  - R01 HL088547/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121030
PL  - England
TA  - Ann Med
JT  - Annals of medicine
JID - 8906388
RN  - 0 (Blood Glucose)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 9007-41-4 (C-Reactive Protein)
RN  - EC 3.4.21.39 (Chymases)
RN  - EC 3.4.21.59 (Tryptases)
SB  - IM
MH  - Aged
MH  - Blood Glucose/analysis
MH  - C-Reactive Protein/analysis
MH  - Chymases/*blood
MH  - Fasting
MH  - Female
MH  - *Glucose Tolerance Test
MH  - Homeostasis
MH  - Humans
MH  - Hypertension/epidemiology
MH  - Immunoglobulin E/*blood
MH  - Insulin-Secreting Cells/physiology
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Prediabetic State/*blood
MH  - Risk Factors
MH  - Sex Factors
MH  - Tryptases/*blood
MH  - Waist Circumference
MH  - Waist-Hip Ratio
PMC - PMC3934348
MID - NIHMS552373
COIS- Declaration of interest: This work was supported by awards from the Huzhou 
      Municipal Science and Technology Agency (2008GS09) (H.Z.), the Zhejiang Province 
      Department of Health (2008B178) (Z.W.), and the Zhejiang Province Department of 
      Education (20070470) (X.H.S.); by grants from the National Institutes of Health 
      HL60942, HL81090, HL88547 (G.P.S.); and by an EIA award (0840118N) from the 
      American Heart Association (G.P.S.). The authors report no conflicts of interest.
EDAT- 2012/11/01 06:00
MHDA- 2013/11/06 06:00
PMCR- 2014/02/25
CRDT- 2012/11/01 06:00
PHST- 2012/11/01 06:00 [entrez]
PHST- 2012/11/01 06:00 [pubmed]
PHST- 2013/11/06 06:00 [medline]
PHST- 2014/02/25 00:00 [pmc-release]
AID - 10.3109/07853890.2012.732234 [doi]
PST - ppublish
SO  - Ann Med. 2013 May;45(3):220-9. doi: 10.3109/07853890.2012.732234. Epub 2012 Oct 
      30.