PMID- 23110937
OWN - NLM
STAT- MEDLINE
DCOM- 20130325
LR  - 20220330
IS  - 1872-8421 (Electronic)
IS  - 0165-5728 (Linking)
VI  - 255
IP  - 1-2
DP  - 2013 Feb 15
TI  - The link between some alleles on human leukocyte antigen system and autism in 
      children.
PG  - 70-4
LID - S0165-5728(12)00305-0 [pii]
LID - 10.1016/j.jneuroim.2012.10.002 [doi]
AB  - The reason behind the initiation of autoimmunity to brain in some patients with 
      autism is not well understood. There is an association between some autoimmune 
      disorders and specific alleles of human leukocyte antigen (HLA) system. Thus, we 
      examined the frequency of some HLA-DRB1 alleles in 100 autistic children and 100 
      healthy matched-children by differential hybridization with sequence-specific 
      oligonucleotide probes. The risk of association between acquisition or absence of 
      these alleles and autism and also a history of autoimmune diseases in autistic 
      relatives was studied. Autistic children had significantly higher frequency of 
      HLA-DRB1*11 allele than controls (P<0.001). In contrast, autistic children had 
      significantly lower frequency of HLA-DRB1*03 allele than controls (P<0.001). 
      Acquisition of HLA-DRB1*011 and absence of HLA-DRB1*3 had significant risk for 
      association with autism (odds ratio: 3.21 and 0.17, respectively; 95% CI: 
      1.65-6.31 and 0.06-0.45, respectively). HLA-DRB1*11 had a significant risk for 
      association with a family history of autoimmunity in autistic children (odds 
      ratio: 5.67; 95% CI: 2.07-16.3). In conclusions, the link of some HLA alleles to 
      autism and to family history of autoimmunity indicates the possible contributing 
      role of these alleles to autoimmunity in some autistic children. Despite a 
      relatively small sample size, we are the first to report a probable protective 
      association of HLA-DRB1*03 allele with autism. It warrants a replication study of 
      a larger sample to validate the HLA-DRB1 genetic association with autism. This is 
      important to determine whether therapeutic modulations of the immune function are 
      legitimate avenues for novel therapy in selected cases of autism.
CI  - Copyright (c) 2012 Elsevier B.V. All rights reserved.
FAU - Mostafa, Gehan A
AU  - Mostafa GA
AD  - Department of Pediatrics, Faculty of Medicine, Ain Shams University, Cairo, 
      Egypt; Autism Research and Treatment Center, Al-Amodi Autism Research Chair, 
      Department of Physiology, Faculty of Medicine, King Saud University, Riyadh, 
      Saudi Arabia. hafezg@softhome.net
FAU - Shehab, Abeer A
AU  - Shehab AA
FAU - Al-Ayadhi, Laila Y
AU  - Al-Ayadhi LY
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121027
PL  - Netherlands
TA  - J Neuroimmunol
JT  - Journal of neuroimmunology
JID - 8109498
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (HLA-DRB1*11 antigen)
SB  - IM
MH  - Autistic Disorder/epidemiology/*genetics/immunology
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Gene Frequency/genetics/immunology
MH  - Genetic Predisposition to Disease/epidemiology/*genetics
MH  - HLA-DRB1 Chains/*genetics/immunology
MH  - Humans
MH  - Male
EDAT- 2012/11/01 06:00
MHDA- 2013/03/26 06:00
CRDT- 2012/11/01 06:00
PHST- 2012/06/28 00:00 [received]
PHST- 2012/09/29 00:00 [revised]
PHST- 2012/10/03 00:00 [accepted]
PHST- 2012/11/01 06:00 [entrez]
PHST- 2012/11/01 06:00 [pubmed]
PHST- 2013/03/26 06:00 [medline]
AID - S0165-5728(12)00305-0 [pii]
AID - 10.1016/j.jneuroim.2012.10.002 [doi]
PST - ppublish
SO  - J Neuroimmunol. 2013 Feb 15;255(1-2):70-4. doi: 10.1016/j.jneuroim.2012.10.002. 
      Epub 2012 Oct 27.