PMID- 23111180
OWN - NLM
STAT- MEDLINE
DCOM- 20130314
LR  - 20220310
IS  - 1879-1891 (Electronic)
IS  - 0002-9394 (Linking)
VI  - 155
IP  - 2
DP  - 2013 Feb
TI  - Computerized assessment of intraretinal and subretinal fluid regions in 
      spectral-domain optical coherence tomography images of the retina.
PG  - 277-286.e1
LID - S0002-9394(12)00559-4 [pii]
LID - 10.1016/j.ajo.2012.07.030 [doi]
AB  - PURPOSE: To evaluate a new computerized segmentation technique for the 
      quantification of intraretinal and subretinal fluid in spectral-domain optical 
      coherence tomography (SD OCT) images of the retina. DESIGN: Prospective, 
      cross-sectional study. METHODS: Thirty-seven B-scan images of 37 patients with 
      exudative age-related macular degeneration were chosen randomly from SD OCT 
      volume scans (1 per volume scan). All hyporeflective areas in the image first 
      were segmented automatically as candidate regions by the program. Researchers who 
      were masked to the candidate region information selected each fluid region from 
      the original image using a single mouse click. The program then delineated the 
      boundary of each region selected and calculated quantitative parameters, 
      including total area of fluid regions if multiple regions were selected. The 
      performance of our technique was validated by comparing the results with the 
      measurements obtained from boundaries manually delineated by 2 masked observers. 
      Time efficiency, agreement with manual delineation, and intraobserver and 
      interobserver agreement of using the program were evaluated. RESULTS: The 
      proposed technique reduced the average processing time per image approximately 
      6-fold (15 seconds for computerized segmentation vs 90 seconds for manual 
      delineation). There was good agreement between computerized segmentation and 
      manual delineation measured by intraclass correlation coefficient (range, 0.897 
      to 0.979) and the Dice coefficient (range, 0.721 to 0.785). The proposed 
      technique has excellent intraobserver and interobserver agreement (intraclass 
      correlation coefficient range, 0.998 to 0.999; Dice coefficient range. 0.959 to 
      0.981). CONCLUSIONS: This computerized segmentation method allows for accurate 
      and fast quantification of fluid in retinal SD OCT images and could assist in 
      monitoring disease progression and evaluating therapeutic intervention.
CI  - Copyright (c) 2013 Elsevier Inc. All rights reserved.
FAU - Zheng, Yalin
AU  - Zheng Y
AD  - Department of Eye and Vision Science, Institute of Ageing and Chronic Disease, 
      University of Liverpool, Liverpool, United Kingdom. yalin.zheng@liv.ac.uk
FAU - Sahni, Jayashree
AU  - Sahni J
FAU - Campa, Claudio
AU  - Campa C
FAU - Stangos, Alexandros N
AU  - Stangos AN
FAU - Raj, Ankur
AU  - Raj A
FAU - Harding, Simon P
AU  - Harding SP
LA  - eng
PT  - Journal Article
PT  - Validation Study
DEP - 20121027
PL  - United States
TA  - Am J Ophthalmol
JT  - American journal of ophthalmology
JID - 0370500
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Cross-Sectional Studies
MH  - Diagnostic Techniques, Ophthalmological
MH  - Exudates and Transudates
MH  - Female
MH  - Humans
MH  - *Image Interpretation, Computer-Assisted
MH  - Macular Degeneration/*diagnosis
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Retina/*pathology
MH  - *Subretinal Fluid
MH  - *Tomography, Optical Coherence
EDAT- 2012/11/01 06:00
MHDA- 2013/03/15 06:00
CRDT- 2012/11/01 06:00
PHST- 2012/02/07 00:00 [received]
PHST- 2012/07/27 00:00 [revised]
PHST- 2012/07/31 00:00 [accepted]
PHST- 2012/11/01 06:00 [entrez]
PHST- 2012/11/01 06:00 [pubmed]
PHST- 2013/03/15 06:00 [medline]
AID - S0002-9394(12)00559-4 [pii]
AID - 10.1016/j.ajo.2012.07.030 [doi]
PST - ppublish
SO  - Am J Ophthalmol. 2013 Feb;155(2):277-286.e1. doi: 10.1016/j.ajo.2012.07.030. Epub 
      2012 Oct 27.