PMID- 23111763
OWN - NLM
STAT- MEDLINE
DCOM- 20130827
LR  - 20211203
IS  - 1536-4801 (Electronic)
IS  - 0277-2116 (Linking)
VI  - 56
IP  - 3
DP  - 2013 Mar
TI  - Celiac disease: the new proposed ESPGHAN diagnostic criteria do work well in a 
      selected population.
PG  - 251-6
LID - 10.1097/MPG.0b013e318279887b [doi]
AB  - BACKGROUND: The need for an early and accurate diagnosis in celiac disease (CD) 
      has focused attention on new diagnostic approaches, based on the efficiency of 
      serological markers and the high negative predictive value of human leukocyte 
      antigen (HLA) non-DQ2/8. METHODS: We performed a retrospective review of all of 
      the patients suspected of having CD who had undergone a small bowel biopsy in our 
      gastroenterology unit. All symptomatic children with serological marker at time 
      of biopsy (immunoglobulin A-tissue transglutaminase antibody, endomysial 
      antibody, and HLA genotype) were included. The triple test (TT) was positive if 
      immunoglobulin A-tissue transglutaminase antibody was 10 times the upper limit of 
      normal, plus positive endomysial antibody plus human leukocyte antigen-DQ2/DQ8. 
      RESULTS: A total of 150 patients met the inclusion criteria and were enrolled in 
      the study. One hundred sixteen were positive for the TT; 113 of 116 (97.4%) had a 
      Marsh 2/3 histological lesion and had been considered to have CD. Thus, positive 
      predictive value of the TT was 97.4%. The other 3 cases (2.6%) had Marsh 0/1 
      lesion, so we consider them to be false-positives for the TT; however, on 
      follow-up, all 3 children developed histological damage after a gluten challenge. 
      Finally, the positive predictive value of the TT was 100%. Thirty-four patients 
      were negative for the TT: 22 patients are celiac, 3 are celiac but challenge 
      gluten diet is pending, and the 9 patients left have other gastrointestinal 
      disorder. CONCLUSIONS: Our study supports the view that in selected children who 
      are symptomatic and positive for the TT, CD diagnosis could be established 
      independent of histological findings.
FAU - Klapp, Gabriela
AU  - Klapp G
AD  - Pediatric Gastroenterology and Hepatology, La Fe University Hospital, Valencia, 
      Spain.
FAU - Masip, Etna
AU  - Masip E
FAU - Bolonio, Miguel
AU  - Bolonio M
FAU - Donat, Ester
AU  - Donat E
FAU - Polo, Begona
AU  - Polo B
FAU - Ramos, David
AU  - Ramos D
FAU - Ribes-Koninckx, Carmen
AU  - Ribes-Koninckx C
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PL  - United States
TA  - J Pediatr Gastroenterol Nutr
JT  - Journal of pediatric gastroenterology and nutrition
JID - 8211545
RN  - 0 (Autoantibodies)
RN  - 0 (Biomarkers)
RN  - 0 (HLA Antigens)
RN  - 0 (Immunoglobulin A)
RN  - EC 2.3.2.13 (Protein Glutamine gamma Glutamyltransferase 2)
RN  - EC 2.3.2.13 (Transglutaminases)
RN  - EC 3.6.1.- (GTP-Binding Proteins)
SB  - IM
CIN - J Pediatr Gastroenterol Nutr. 2013 Mar;56(3):241. PMID: 23085890
MH  - Adolescent
MH  - Autoantibodies/*analysis
MH  - Biomarkers/blood
MH  - Celiac Disease/blood/*diagnosis/immunology/pathology
MH  - Child
MH  - Child, Preschool
MH  - Europe
MH  - Female
MH  - Follow-Up Studies
MH  - GTP-Binding Proteins/*antagonists & inhibitors
MH  - HLA Antigens/analysis/*genetics
MH  - Haplotypes
MH  - Humans
MH  - Immunoglobulin A/analysis
MH  - Infant
MH  - Intestinal Mucosa/pathology
MH  - Male
MH  - Muscle Fibers, Skeletal/*immunology
MH  - *Practice Guidelines as Topic
MH  - Predictive Value of Tests
MH  - Protein Glutamine gamma Glutamyltransferase 2
MH  - Retrospective Studies
MH  - Societies, Scientific
MH  - Transglutaminases/*antagonists & inhibitors
EDAT- 2012/11/01 06:00
MHDA- 2013/08/28 06:00
CRDT- 2012/11/01 06:00
PHST- 2012/11/01 06:00 [entrez]
PHST- 2012/11/01 06:00 [pubmed]
PHST- 2013/08/28 06:00 [medline]
AID - 10.1097/MPG.0b013e318279887b [doi]
PST - ppublish
SO  - J Pediatr Gastroenterol Nutr. 2013 Mar;56(3):251-6. doi: 
      10.1097/MPG.0b013e318279887b.