PMID- 23111884
OWN - NLM
STAT- MEDLINE
DCOM- 20130826
LR  - 20131121
IS  - 1477-0903 (Electronic)
IS  - 0960-3271 (Linking)
VI  - 32
IP  - 3
DP  - 2013 Mar
TI  - Estimation of BDNF gene polymorphism and predisposition to dependence development 
      for selected psychoactive compounds: genetic aspects of addiction with the 
      selected drugs, amphetamine, tetrahydrocannabinol and opiates.
PG  - 236-40
LID - 10.1177/0960327112459203 [doi]
AB  - The etiology of drug addiction, a central nervous system (CNS) disease, is not 
      fully known. This complex problem is believed to be connected with concurrently 
      affecting genetic, psychological and environmental factors. The development of 
      addiction is connected with CNS reinforcement system and dopaminergic 
      neurotransmission. Molecular processes are postulated to be of universal 
      character and allow to presume a similar mechanism of dependence for both ethanol 
      and other substances. Therefore, elements of dopaminergic transmission become 
      excellent candidates for the examination of genetic influence on the development 
      of addiction. A relationship between alcoholic disease and the presence of TaqIA1 
      and DRD2 alleles permits to initiate another investigation of gene-coding DRD2 
      dopamine receptor. The latest results indicate the importance of brain-derived 
      neurotrophic factor (BDNF) in the regulation of dopaminergic route. The purpose 
      of this research was to reveal the relationship between the Val66Met BDNF gene 
      polymorphism and dependence of psychoactive agent. The examinations were 
      performed with the Local Research Ethics Committee approval and patient's 
      consent. The study group consisted of 100 patients (88 men and 12 women) aged 
      18-52 years, qualified for research program according to the International 
      Classification of Diseases, Tenth Revision (ICD-10) requirements, medical 
      examination and detailed questionnaire.
FAU - Biskupska, J
AU  - Biskupska J
AD  - Division of Clinical Toxicology and Pathobiochemistry, Department of Forensic 
      Medicine, Pomeranian University of Medicine, Szczecin, Poland.
FAU - Borowiak, K S
AU  - Borowiak KS
FAU - Karlin-Grazewicz, K
AU  - Karlin-Grazewicz K
FAU - Janus, T
AU  - Janus T
FAU - Waloszczyk, P
AU  - Waloszczyk P
FAU - Potocka-Banas, B
AU  - Potocka-Banas B
FAU - Machoy-Mokrzynska, A
AU  - Machoy-Mokrzynska A
FAU - Ossowski, A
AU  - Ossowski A
FAU - Ciechanowicz, A
AU  - Ciechanowicz A
LA  - eng
PT  - Journal Article
DEP - 20121030
PL  - England
TA  - Hum Exp Toxicol
JT  - Human & experimental toxicology
JID - 9004560
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Opiate Alkaloids)
RN  - 0 (Psychotropic Drugs)
RN  - 7J8897W37S (Dronabinol)
RN  - CK833KGX7E (Amphetamine)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Amphetamine
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Dronabinol
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Opiate Alkaloids
MH  - Polymorphism, Genetic
MH  - Psychotropic Drugs
MH  - Substance-Related Disorders/*genetics
MH  - Young Adult
EDAT- 2012/11/01 06:00
MHDA- 2013/08/27 06:00
CRDT- 2012/11/01 06:00
PHST- 2012/11/01 06:00 [entrez]
PHST- 2012/11/01 06:00 [pubmed]
PHST- 2013/08/27 06:00 [medline]
AID - 0960327112459203 [pii]
AID - 10.1177/0960327112459203 [doi]
PST - ppublish
SO  - Hum Exp Toxicol. 2013 Mar;32(3):236-40. doi: 10.1177/0960327112459203. Epub 2012 
      Oct 30.