PMID- 23113968
OWN - NLM
STAT- MEDLINE
DCOM- 20130308
LR  - 20211021
IS  - 1471-2202 (Electronic)
IS  - 1471-2202 (Linking)
VI  - 13
DP  - 2012 Oct 31
TI  - Prepulse inhibition of auditory change-related cortical responses.
PG  - 135
LID - 10.1186/1471-2202-13-135 [doi]
AB  - BACKGROUND: Prepulse inhibition (PPI) of the startle response is an important 
      tool to investigate the biology of schizophrenia. PPI is usually observed by use 
      of a startle reflex such as blinking following an intense sound. A similar 
      phenomenon has not been reported for cortical responses. RESULTS: In 12 healthy 
      subjects, change-related cortical activity in response to an abrupt increase of 
      sound pressure by 5 dB above the background of 65 dB SPL (test stimulus) was 
      measured using magnetoencephalography. The test stimulus evoked a clear cortical 
      response peaking at around 130 ms (Change-N1m). In Experiment 1, effects of the 
      intensity of a prepulse (0.5 ~ 5 dB) on the test response were examined using a 
      paired stimulation paradigm. In Experiment 2, effects of the interval between the 
      prepulse and test stimulus were examined using interstimulus intervals (ISIs) of 
      50 ~ 350 ms. When the test stimulus was preceded by the prepulse, the Change-N1m 
      was more strongly inhibited by a stronger prepulse (Experiment 1) and a shorter 
      ISI prepulse (Experiment 2). In addition, the amplitude of the test Change-N1m 
      correlated positively with both the amplitude of the prepulse-evoked response and 
      the degree of inhibition, suggesting that subjects who are more sensitive to the 
      auditory change are more strongly inhibited by the prepulse. CONCLUSIONS: Since 
      Change-N1m is easy to measure and control, it would be a valuable tool to 
      investigate mechanisms of sensory gating or the biology of certain mental 
      diseases such as schizophrenia.
FAU - Inui, Koji
AU  - Inui K
AD  - Department of Integrative Physiology, National Institute for Physiological 
      Sciences, Okazaki, 444-8585, Japan. inui@nips.ac.jp
FAU - Tsuruhara, Aki
AU  - Tsuruhara A
FAU - Kodaira, Minori
AU  - Kodaira M
FAU - Motomura, Eishi
AU  - Motomura E
FAU - Tanii, Hisashi
AU  - Tanii H
FAU - Nishihara, Makoto
AU  - Nishihara M
FAU - Keceli, Sumru
AU  - Keceli S
FAU - Kakigi, Ryusuke
AU  - Kakigi R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121031
PL  - England
TA  - BMC Neurosci
JT  - BMC neuroscience
JID - 100966986
SB  - IM
MH  - Acoustic Stimulation/methods
MH  - Adult
MH  - Analysis of Variance
MH  - Auditory Cortex/*physiology
MH  - Electromyography
MH  - Evoked Potentials, Auditory/*physiology
MH  - Female
MH  - Humans
MH  - *Inhibition, Psychological
MH  - Magnetoencephalography
MH  - Male
MH  - Middle Aged
MH  - Psychoacoustics
MH  - Reaction Time
MH  - Reflex, Startle
MH  - Reproducibility of Results
MH  - Sensory Gating/*physiology
MH  - Time Factors
PMC - PMC3502566
EDAT- 2012/11/02 06:00
MHDA- 2013/03/09 06:00
PMCR- 2012/10/31
CRDT- 2012/11/02 06:00
PHST- 2012/07/31 00:00 [received]
PHST- 2012/10/25 00:00 [accepted]
PHST- 2012/11/02 06:00 [entrez]
PHST- 2012/11/02 06:00 [pubmed]
PHST- 2013/03/09 06:00 [medline]
PHST- 2012/10/31 00:00 [pmc-release]
AID - 1471-2202-13-135 [pii]
AID - 10.1186/1471-2202-13-135 [doi]
PST - epublish
SO  - BMC Neurosci. 2012 Oct 31;13:135. doi: 10.1186/1471-2202-13-135.