PMID- 23114793
OWN - NLM
STAT- MEDLINE
DCOM- 20140113
LR  - 20220316
IS  - 1543-2742 (Electronic)
IS  - 1526-484X (Linking)
VI  - 23
IP  - 3
DP  - 2013 Jun
TI  - Increase in skeletal-muscle glycogenolysis and perceived exertion with 
      progressive dehydration during cycling in hydrated men.
PG  - 220-9
AB  - This study investigated the effects of progressive mild dehydration during 
      cycling on whole-body substrate oxidation and skeletal-muscle metabolism in 
      recreationally active men. Subjects (N = 9) cycled for 120 min at ~65% peak 
      oxygen uptake (VO2peak 22.7  degrees C, 32% relative humidity) with water to replace 
      sweat losses (HYD) or without fluid (DEH). Blood samples were taken at rest and 
      every 20 min, and muscle biopsies were taken at rest and at 40, 80, and 120 min 
      of exercise. Subjects lost 0.8%, 1.8%, and 2.7% body mass (BM) after 40, 80, and 
      120 min of cycling in the DEH trial while sweat loss was not significantly 
      different between trials. Heart rate was greater in the DEH trial from 60 to 120 
      min, and core temperature was greater from 75 to 120 min. Rating of perceived 
      exertion was higher in the DEH trial from 30 to 120 min. There were no 
      differences in VO2, respiratory-exchange ratio, total carbohydrate (CHO) 
      oxidation (HYD 312 +/- 9 vs. DEH 307 +/- 10 g), or sweat rate between trials. Blood 
      lactate was significantly greater in the DEH trial from 20 to 120 min with no 
      difference in plasma free fatty acids or epinephrine. Glycogenolysis was 
      significantly greater (24%) over the entire DEH vs. HYD trial (433 +/- 44 vs. 349 +/- 
      27 mmol . kg-1 . dm-1). In conclusion, dehydration of <2% BM elevated 
      physiological parameters and perceived exertion, as well as muscle 
      glycogenolysis, during exercise without affecting whole-body CHO oxidation.
FAU - Logan-Sprenger, Heather M
AU  - Logan-Sprenger HM
AD  - Dept. of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON, 
      Canada.
FAU - Heigenhauser, George J F
AU  - Heigenhauser GJ
FAU - Jones, Graham L
AU  - Jones GL
FAU - Spriet, Lawrence L
AU  - Spriet LL
LA  - eng
PT  - Journal Article
DEP - 20121030
PL  - United States
TA  - Int J Sport Nutr Exerc Metab
JT  - International journal of sport nutrition and exercise metabolism
JID - 100939812
RN  - 0 (Fatty Acids, Nonesterified)
RN  - 33X04XA5AT (Lactic Acid)
SB  - IM
MH  - Bicycling/*physiology
MH  - Body Mass Index
MH  - Dehydration/metabolism
MH  - Energy Metabolism/*physiology
MH  - Exercise/*physiology
MH  - Fatty Acids, Nonesterified/blood
MH  - Glycogenolysis/*physiology
MH  - Heart Rate/physiology
MH  - Humans
MH  - Lactic Acid/blood
MH  - Male
MH  - Muscle, Skeletal/*metabolism
MH  - Oxygen Consumption/physiology
MH  - Sweat/metabolism
MH  - Sweating/physiology
MH  - Young Adult
EDAT- 2012/11/02 06:00
MHDA- 2014/01/15 06:00
CRDT- 2012/11/02 06:00
PHST- 2012/11/02 06:00 [entrez]
PHST- 2012/11/02 06:00 [pubmed]
PHST- 2014/01/15 06:00 [medline]
AID - 2012-0071 [pii]
AID - 10.1123/ijsnem.23.3.220 [doi]
PST - ppublish
SO  - Int J Sport Nutr Exerc Metab. 2013 Jun;23(3):220-9. doi: 10.1123/ijsnem.23.3.220. 
      Epub 2012 Oct 30.